Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic information about accelerated aging among people with rheumatoid arthritis

13.11.2006
The observation that people with rheumatoid arthritis (RA) die at a younger age than people without this disease is not new, but arthritis experts don't fully understand the causes of the increased mortality rates.

Laboratory scientists have observed that RA and other diseases can cause multiple systems within the body to age more rapidly than expected. Cells affected by diseases begin to show signs of what's called accelerated aging -- damage at the molecular level resulting in poorer function.

Mayo researchers attending the American College of Rheumatology Annual Meeting will share preliminary findings that suggest increased mortality among people with RA is consistent with the concept of accelerated aging.

The Mayo research team conducted a population-based study that included 393 people diagnosed with RA. Examining medical records for the RA patients, Mayo researchers recorded the subjects' age at death and underlying cause of death. They compared the data from RA patients to expected survival data for people with similar birth dates and genders from the general population (obtained from the National Center for Health Statistics).

Mayo researchers then applied a novel mathematical tool to analyze the mortality data -- an accelerated failure time model. Doing this allowed researchers to estimate an "acceleration factor" that quantifies the rate of aging occurring among the study subjects with RA.

Significant findings: As expected, the observed survival rate for people with RA was consistently less than the expected survival rates for people in the general population. Researchers estimated that the RA patients in the study group aged at approximately 1.25 times the rate of people in the general population. Another way to express this finding is that during each 10-year time span, people with RA, in effect, age 12.5. "We've known for decades that the mortality rate among people with rheumatoid arthritis is higher, and that these patients are at increased risk for heart and lung disease," explains lead researcher and Mayo epidemiologist Sherine Gabriel, M.D. "With this study, we've now applied a mathematical model that shows consistency between our observed mortality rates and our understanding of the concept of accelerated aging."

Dr. Gabriel explains that new knowledge about this acceleration factor also underscores the need for people with RA to be aware of their increased health risks and to seek medical care that addresses their total health.

"Because rheumatoid arthritis is chronic and can be so consuming, patients and their doctors sometimes pay less attention to other issues, like cardiovascular health," notes Dr. Gabriel. "Studies like these remind us that early diagnosis and intervention are extremely important for these patients."

Future research likely will focus on establishing a closer link between the Mayo findings and laboratory studies of cellular aging.

Sara Lee | EurekAlert!
Further information:
http://www.mayoclinic.com
http://www.mayoclinic.org/news

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>