Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic information about accelerated aging among people with rheumatoid arthritis

13.11.2006
The observation that people with rheumatoid arthritis (RA) die at a younger age than people without this disease is not new, but arthritis experts don't fully understand the causes of the increased mortality rates.

Laboratory scientists have observed that RA and other diseases can cause multiple systems within the body to age more rapidly than expected. Cells affected by diseases begin to show signs of what's called accelerated aging -- damage at the molecular level resulting in poorer function.

Mayo researchers attending the American College of Rheumatology Annual Meeting will share preliminary findings that suggest increased mortality among people with RA is consistent with the concept of accelerated aging.

The Mayo research team conducted a population-based study that included 393 people diagnosed with RA. Examining medical records for the RA patients, Mayo researchers recorded the subjects' age at death and underlying cause of death. They compared the data from RA patients to expected survival data for people with similar birth dates and genders from the general population (obtained from the National Center for Health Statistics).

Mayo researchers then applied a novel mathematical tool to analyze the mortality data -- an accelerated failure time model. Doing this allowed researchers to estimate an "acceleration factor" that quantifies the rate of aging occurring among the study subjects with RA.

Significant findings: As expected, the observed survival rate for people with RA was consistently less than the expected survival rates for people in the general population. Researchers estimated that the RA patients in the study group aged at approximately 1.25 times the rate of people in the general population. Another way to express this finding is that during each 10-year time span, people with RA, in effect, age 12.5. "We've known for decades that the mortality rate among people with rheumatoid arthritis is higher, and that these patients are at increased risk for heart and lung disease," explains lead researcher and Mayo epidemiologist Sherine Gabriel, M.D. "With this study, we've now applied a mathematical model that shows consistency between our observed mortality rates and our understanding of the concept of accelerated aging."

Dr. Gabriel explains that new knowledge about this acceleration factor also underscores the need for people with RA to be aware of their increased health risks and to seek medical care that addresses their total health.

"Because rheumatoid arthritis is chronic and can be so consuming, patients and their doctors sometimes pay less attention to other issues, like cardiovascular health," notes Dr. Gabriel. "Studies like these remind us that early diagnosis and intervention are extremely important for these patients."

Future research likely will focus on establishing a closer link between the Mayo findings and laboratory studies of cellular aging.

Sara Lee | EurekAlert!
Further information:
http://www.mayoclinic.com
http://www.mayoclinic.org/news

More articles from Health and Medicine:

nachricht A better way to measure the stiffness of cancer cells
01.03.2017 | Duke University

nachricht Humans have three times more brown body fat
01.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

A better way to measure the stiffness of cancer cells

01.03.2017 | Health and Medicine

Exploring the mysteries of supercooled water

01.03.2017 | Physics and Astronomy

Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth

01.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>