Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New way of tracking muscle damage from radiation

08.11.2006
St. Jude team shows magnetic resonance imaging (MRI) holds promise for predicting long-term damage to children's muscles, enabling doctors to better avoid it

Magnetic resonance imaging (MRI) could become a valuable tool for predicting the risk of muscle injury during and following radiation therapy, according to investigators at St. Jude Children's Research Hospital.

The researchers report that MRI can spot the immediate injury done by radiation therapy to the muscles of children undergoing radiation treatment for certain types of soft-tissue cancer. This also indicates that MRI might one day be able to help doctors predict the amount of long-term damage that radiation may cause. A report on these findings appears in the Oct. 25 online issue of Magnetic Resonance Imaging.

The study's findings are significant because as radiation treatments become more advanced and complex, clinicians must have a way to predict the outcomes--including side effects--on specific patients, according to Matthew Krasin, M.D., associate member of the St. Jude Department of Radiological Sciences.

The St. Jude study showed that changes in images taken of muscles before and after radiation therapy for soft tissue sarcoma and Ewing sarcoma are related not only to the amount of radiation the child received, but also to the child's age and the presence of a nearby tumor.

"We hope that detecting these changes at such an early stage may help clinicians predict which patients need an intervention to prevent late damage," Krasin said. Soft tissue sarcomas are cancers that arise in muscles, fat, blood vessels and other soft tissues. Ewing sarcoma is a cancer that arises in the bone or soft tissue, usually in the arms, legs, pelvis or chest wall.

St. Jude researchers studied the muscles of 13 patients before, during and 12 weeks after they received radiation therapy for soft tissue sarcoma. The team used a technique called quantitative T2 to determine the extent of swelling in tissues before, during and after radiation therapy; and a technique called dynamic enhanced magnetic resonance imaging (DEMRI) to study what happens to the blood supply at a microscopic level.

"These techniques are powerful, non-surgical ways to look into the body and study the microscopic and biochemical changes that are occurring in each patient after radiation therapy," Krasin said.

The team made 60 images of the same area, including a dynamic view of what was happening in the muscles during a six-minute period following infusion of gadolinium, a contrast agent.

"The rate at which the contrast agent flows in and out of a region, or whether it leaks out of the blood vessel, helps us understand whether the blood supply is in poor or good condition," Krasin said. "Changes in T2 measurements may indicate an increase in swelling following radiation therapy, which is evidence of inflammation that could be treated."

The researchers believe that the early changes they see in muscle, such as swelling and leakage, might help them predict how much damage will occur in the muscles during the course of many months. By better understanding what causes these changes, clinicians will then be able to design better radiation treatments to avoid potential problems or treat the injury at an earlier stage, Krasin said.

Bonnie Kourvelas | EurekAlert!
Further information:
http://www.stjude.org

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>