Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers use magnetic attraction to improve stents, reduce blood clot risk

03.11.2006
Mayo Clinic heart researchers have devised a new strategy to improve the effectiveness and safety of heart stents, which are used to open narrowed blood vessels and have been the recent subject of clotting concerns. Their novel approach is based on magnetizing healing cells from the patient's blood so the cells are quickly drawn to magnetically coated stents.

The research report appears in the Nov. 7 issue of the Journal of the American College of Cardiology (http://content.onlinejacc.org/). The Mayo team describes encouraging results from preclinical testing.

In the study, the cells were extracted from blood, and tiny iron-based paramagnetic particles were placed within the cells. Each stent was implanted through a tube (catheter) threaded through the blood vessels. Researchers then introduced the iron-tagged cells back into the blood vessel to test how well the magnetized stents captured the cells.

Because the healing cells -- also known as endothelial progenitor cells derived from circulating blood -- naturally fight blood clot formation, their swift magnetically guided arrival to the stent may reduce the chances of blood clot formation by lining the site fully and quickly, Mayo researchers say.

Results show a sixfold to 30-fold improvement in the magnetized stents' performance in capturing the healing endothelial cells, compared to the standard stents' ability to do so.

"The ability to rapidly coat implanted devices with living cells could accelerate local tissue healing and thereby reduce the risk of blood clot formation," says cardiologist Gurpreet Sandhu, M.D., Ph.D., lead investigator. "Our approach of magnetic cell targeting is the next generation of strategies for improving the safety of stents -- and it appears that magnetic forces may provide an elegant solution for cell capture. Additionally, this new magnetic targeting technology can be adapted to develop new cell-, gene- and drug-based treatments for cancer and other human diseases."

Dr. Sandhu adds that, while encouraging, the method is still experimental and not ready to be used on human patients. Researchers are refining their approach, including developing new biomaterials.

Significance of the Mayo Research

"Many people are currently concerned about the risk of blood clots associated in a small percentage of patients with the use of drug-eluting stents," says cardiologist and cardiac researcher Robert Simari, M.D., who co-authored the paper. "Our approach holds the potential to overcome the limitations of the current drug-eluting stent technology because we address the basic conditions of clot formation. One of the reasons clots can form in drug-eluting stent patients is that the area surrounding the stent is not relined fully or quickly enough with the cells in the body, called endothelial cells, that naturally fight blood clots. Our system delivers endothelial cells right where they need to be, rapidly, with the potential for limiting clot formation."

How It Works

Multiple steps led to the development of the new Mayo magnetic cell targeting stent system. For example, the researchers had to devise:

o a way to successfully get endothelial cells derived from blood and grown in lab dishes to live and proliferate when tagged with tiny amounts of magnetically responsive material known as iron-based paramagnetic microspheres.

o specially fabricated stainless steel stents coated with magnetic materials that demonstrated excellent ability to capture the magnetically tagged endothelial cells.

Traci Klein | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Health and Medicine:

nachricht Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Nerves control the body’s bacterial community

26.09.2017 | Life Sciences

Four elements make 2-D optical platform

26.09.2017 | Physics and Astronomy

Goodbye, login. Hello, heart scan

26.09.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>