It was shown conclusively in the 1980s that ulcers are caused by the bacterium Helicobacter pylori, a discovery that earned two Australian scientists the Nobel Prize for Medicine in 2005. It is also well established today that a Helicobacter infection is the greatest risk factor for stomach cancer, one of our most common cancer forms.
The adhesion of this bacterium to the mucous lining of the stomach is generally seen as an important first stage in developing symptoms and incipient disease, such as gastritus. To be able to stick to cell surfaces, H. pylori uses so-called adhesive proteins. They are located on the surface of the bacterium and attach to various sugar molecules on the surface of the stomach cells, which provides the bacteria with a firm grip in the turbulent environment of the stomach.
In the article it is now shown that in an infection the bacteria make their way beyond the cell surfaces of the stomach to the underlying blood vessels. Once there, they can also get through the vessel walls and attach to red blood corpuscles. In this way, Helicobacter can transport themselves elsewhere in the body.
Marina Aspholm, the lead author of this work, has also succeeded in showing that H. pylori use the so-called SabA protein in their adhesion to red corpuscles. What’s more, this protein was shown to vary somewhat across Helicobacter bacteria from different patients. This means that the SabA protein is able to adapt to individuals in order to attain the best adhesion.
During an infection, H. pylori can thus adapt its adhesive properties both to the individual stomach lining and to the changes that take place there in the course of a chronic infection and inflammation.
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24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
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The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
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A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
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At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
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There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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