Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Umeå researchers find ulcer bacteria in blood

27.10.2006
In the journal PloS, Professor Thomas Borén and his research team at Umeå University in Sweden, working together with scientists in Methesda, Maryland, show for the first time that the so-called ulcer bacterium, Helicobacter pylori can spread to and via the blood.

It was shown conclusively in the 1980s that ulcers are caused by the bacterium Helicobacter pylori, a discovery that earned two Australian scientists the Nobel Prize for Medicine in 2005. It is also well established today that a Helicobacter infection is the greatest risk factor for stomach cancer, one of our most common cancer forms.

The adhesion of this bacterium to the mucous lining of the stomach is generally seen as an important first stage in developing symptoms and incipient disease, such as gastritus. To be able to stick to cell surfaces, H. pylori uses so-called adhesive proteins. They are located on the surface of the bacterium and attach to various sugar molecules on the surface of the stomach cells, which provides the bacteria with a firm grip in the turbulent environment of the stomach.

In the article it is now shown that in an infection the bacteria make their way beyond the cell surfaces of the stomach to the underlying blood vessels. Once there, they can also get through the vessel walls and attach to red blood corpuscles. In this way, Helicobacter can transport themselves elsewhere in the body.

Marina Aspholm, the lead author of this work, has also succeeded in showing that H. pylori use the so-called SabA protein in their adhesion to red corpuscles. What’s more, this protein was shown to vary somewhat across Helicobacter bacteria from different patients. This means that the SabA protein is able to adapt to individuals in order to attain the best adhesion.

During an infection, H. pylori can thus adapt its adhesive properties both to the individual stomach lining and to the changes that take place there in the course of a chronic infection and inflammation.

Hans Fällman | alfa
Further information:
http://pathogens.plosjournals.org/
http://www.umu.se

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>