Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Umeå researchers find ulcer bacteria in blood

27.10.2006
In the journal PloS, Professor Thomas Borén and his research team at Umeå University in Sweden, working together with scientists in Methesda, Maryland, show for the first time that the so-called ulcer bacterium, Helicobacter pylori can spread to and via the blood.

It was shown conclusively in the 1980s that ulcers are caused by the bacterium Helicobacter pylori, a discovery that earned two Australian scientists the Nobel Prize for Medicine in 2005. It is also well established today that a Helicobacter infection is the greatest risk factor for stomach cancer, one of our most common cancer forms.

The adhesion of this bacterium to the mucous lining of the stomach is generally seen as an important first stage in developing symptoms and incipient disease, such as gastritus. To be able to stick to cell surfaces, H. pylori uses so-called adhesive proteins. They are located on the surface of the bacterium and attach to various sugar molecules on the surface of the stomach cells, which provides the bacteria with a firm grip in the turbulent environment of the stomach.

In the article it is now shown that in an infection the bacteria make their way beyond the cell surfaces of the stomach to the underlying blood vessels. Once there, they can also get through the vessel walls and attach to red blood corpuscles. In this way, Helicobacter can transport themselves elsewhere in the body.

Marina Aspholm, the lead author of this work, has also succeeded in showing that H. pylori use the so-called SabA protein in their adhesion to red corpuscles. What’s more, this protein was shown to vary somewhat across Helicobacter bacteria from different patients. This means that the SabA protein is able to adapt to individuals in order to attain the best adhesion.

During an infection, H. pylori can thus adapt its adhesive properties both to the individual stomach lining and to the changes that take place there in the course of a chronic infection and inflammation.

Hans Fällman | alfa
Further information:
http://pathogens.plosjournals.org/
http://www.umu.se

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>