The term bicuspid aortal valve means that the valve between the left cardiac ventricle and the aorta has two flaps (cusps) instead of the normal three. This defect often leads to complications such as a widening of the aorta, leakage or constriction of the valve, and subsequent heart surgery. Patients with normal tricuspid aortal valves can also suffer from valve-related diseases, but not to the same extent as those with bicuspid valves.
The reason why so many people are born with a defective valve is not fully known. Nor do scientists know why only some of these patients develop problems with the valve and the aorta. More research is also needed into how these patients should undergo surgery for the best results. Researchers are inclined to favour what is known as valve-sparing surgery (which reconstructs the valve) over total valve replacement, something which they will now be examining more closely. A total of 600 patients will be taking part in the study, which is unique in its kind.
The project is led by Professor Anders Franco-Cereceda from KI’s Division of Thorax Surgery and Thorax Anaesthesiology. With him are Professor Anders Hamsten and Senior Lecturer Per Eriksson from the Atherosclerosis Research Unit at KI, Professor Kenneth Caidahl and associate professor Maria Eriksson from the Division of Clinical Physiology at KI, and associate professor Jan Liska of Karolinska University Hospital’s Thorax Clinic.
Industrialist Fredrik Lundberg is contributing a private donation of 18 million kronor (about 1.9 million euro) to the research project. Mr Lundberg is a major shareholder in Holmen, Hufvudstaden, Cardo and Industrivärden through the investment company that bears his name.
“We’re overwhelmed by his generosity, which is not only important to the actual study but also for making sure that Sweden keeps hold of its competent researchers,” says Professor Franco-Cereceda. ”This project is unique in that we’ll be looking at everything, from genetic causes to the consequences of different surgical methods and aftercare.”
Katarina Sternudd | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy