The term bicuspid aortal valve means that the valve between the left cardiac ventricle and the aorta has two flaps (cusps) instead of the normal three. This defect often leads to complications such as a widening of the aorta, leakage or constriction of the valve, and subsequent heart surgery. Patients with normal tricuspid aortal valves can also suffer from valve-related diseases, but not to the same extent as those with bicuspid valves.
The reason why so many people are born with a defective valve is not fully known. Nor do scientists know why only some of these patients develop problems with the valve and the aorta. More research is also needed into how these patients should undergo surgery for the best results. Researchers are inclined to favour what is known as valve-sparing surgery (which reconstructs the valve) over total valve replacement, something which they will now be examining more closely. A total of 600 patients will be taking part in the study, which is unique in its kind.
The project is led by Professor Anders Franco-Cereceda from KI’s Division of Thorax Surgery and Thorax Anaesthesiology. With him are Professor Anders Hamsten and Senior Lecturer Per Eriksson from the Atherosclerosis Research Unit at KI, Professor Kenneth Caidahl and associate professor Maria Eriksson from the Division of Clinical Physiology at KI, and associate professor Jan Liska of Karolinska University Hospital’s Thorax Clinic.
Industrialist Fredrik Lundberg is contributing a private donation of 18 million kronor (about 1.9 million euro) to the research project. Mr Lundberg is a major shareholder in Holmen, Hufvudstaden, Cardo and Industrivärden through the investment company that bears his name.
“We’re overwhelmed by his generosity, which is not only important to the actual study but also for making sure that Sweden keeps hold of its competent researchers,” says Professor Franco-Cereceda. ”This project is unique in that we’ll be looking at everything, from genetic causes to the consequences of different surgical methods and aftercare.”
Katarina Sternudd | alfa
Fast-tracking T cell therapies with immune-mimicking biomaterials
16.01.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard
Dengue takes low and slow approach to replication
12.01.2018 | Duke University
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
16.01.2018 | Materials Sciences
16.01.2018 | Materials Sciences
16.01.2018 | Power and Electrical Engineering