"Children living in inner cities are exposed to higher allergen levels and tend to have more severe asthma than children living elsewhere," said Dr. Rebecca Gruchalla, chief of allergy at UT Southwestern. "We want to see whether this new treatment can help children with allergic asthma, for which the environmental factors are more difficult to control."
Indoor allergens commonly found in inner cities, such as dust mites, cockroaches, molds and animal dander, are significant allergens that may contribute to the severity of a child's asthma. UT Southwestern, along with 10 other sites around the country, is participating in a National Institutes of Health-supported evaluation of anti-IgE therapy for children. This therapy is already being used successfully in adults and adolescents who have asthma.
"IgE antibodies are the fuel in the immune system that perpetuates the asthmatic reaction," said Dr. Gruchalla, serves as principal investigator at the Dallas site. Some people are more genetically prone to develop IgE antibodies, which are molecules produced by white blood cells in response to exposure to allergens. IgE antibodies can make asthma worse in those people who are sensitive to particular allergens.
The Inner City Anti-IgE Therapy for Asthma (ICATA) study involves about 50 children at each site. It will evaluate Xolair (omalizumab), a drug that binds to and inactivates IgE antibodies.
"Xolair 'sops up' the IgE that's there, decreases the receptors for IgE, and regulates many things that pertain to allergy and the asthmatic response," Dr. Gruchalla said.
The two-year Dallas portion of the study targets children 6 to 20 years old who reside within the Dallas Independent School District. Individuals interested in participating should call 214-648-5436 for additional requirements and information.
Participating children will receive an injection every two or four weeks and medical care for their asthma for nearly two years. Laboratory analyses of biological and environmental samples from the home also will occur during the same time period.
The $15 million study is funded through the Inner-City Asthma Consortium (ICAC), an NIH-sponsored, $55.8 million, six-year contract to investigate treatments and causes of asthma in urban children. Novartis Pharmaceuticals Corp. and Genentech, which are providing about $8 million toward the study, are also donating an additional $6 million in medication. The balance of funding will be provided by the National Institute of Allergy and Infectious Diseases.
The consortium is administered by the University of Wisconsin-Madison. Other research sites in addition to UT Southwestern are: the University of Arizona, Boston University, Children's Memorial Hospital in Chicago, Rainbow Babies and Children's Hospital in Cleveland, Children's National Medical Center in Washington, D.C., National Jewish Medical and Research Center in Denver, Johns Hopkins University, Mount Sinai School of Medicine, and St. Louis Children's Hospital.
Dr. Gruchalla has led the Dallas arm of the Inner City Asthma Consortium for four years. She is also principal investigator of an asthma screening project in Dallas schools and project director for Community Leadership in Preventing Asthma, a study evaluating links between asthma-associated morbidity and allergen levels in schools and homes.
Other UT Southwestern investigators in the ICATA study are Dr. William Neaville, assistant professor of pediatrics and internal medicine, and Dr. Vanthaya Gan, professor of pediatrics.
Russell Rian | EurekAlert!
Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.
So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
28.10.2016 | Power and Electrical Engineering
28.10.2016 | Life Sciences
28.10.2016 | Life Sciences