However until now it has not been clear whether folate supplementation might interact with certain antimalarial drugs which are commonly used to treat and / or prevent malaria infection. In some African countries, folate is commonly given at a higher dose than generally recommended because this dose is more easily available.
Annemieke van Eijk, from the University of Amsterdam, and her colleagues from the Centers for Disease Control and the Kenya Medical Research Institute, therefore carried out a randomized trial, comparing failure of antimalarial treatment with a drug called sulfadoxine-pyrimethamine, in 415 pregnant Kenyan women.
The women then received either a low dose of folate, a high dose of folate (currently recommended in Kenya for pregnant women), or placebo tablets. In the trial, women receiving the higher dose of folate were approximately twice as likely to fail treatment with sulfadoxine-pyrimethamine than women receiving the low dose, or placebo.
This is important information for countries using sulfadoxine-pyrimethamine for the treatment or prevention of malaria in pregnancy. Because of the increased treatment failure of sulfadoxine pyrimethamine for malaria when it is given with high daily doses of folate (such as 5 mg), this kind of dosage should be avoided in the antenatal clinics of these countries. National malaria programs and programs for reproductive health should evaluate the need to change their national policies for folate supplementation during pregnancy. This information needs to be widely and freely available; for this reason we chose PLoS Clinical Trials for publication.
The results are published in PLoS Clinical Trials, an open-access journal that aims to increase the reporting of clinical trials. José Belizan, from the Institute for Clinical Effectiveness, Argentina, an editorial board member for PLoS Clinical Trials, comments: "As a result of trials conducted in the last three to four decades, many aspects of maternal care are now evidence-based. However, others in use still lack rigorous evaluation, and we need innovative, proven practices to improve outcomes for mothers and children. PLoS Clinical Trials represents a unique forum where new and challenging trials will be published, including those from developing countries".
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
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