Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Unexpected findings about development of nervous system

18.10.2006
In his dissertation work, Per-Henrik Edqvist at Uppsala University in Sweden has characterized the molecular development of the retina in the eye with the aim of understanding how the nervous system develops. He has attained several unexpected results that may be of importance to the future treatment of damage to the nervous system.

The retina of the eye, which is part of the central nervous system, is where visual impressions take their initial shape. The retina consists of photoreceptors and several different specialized nerve cells that use various networks to coordinate impressions from the light-sensitive photoreceptors before the information is relayed to the brain.

Per-Henrik Edqvist has studied how the retina’s complex structure of specialized cells is formed from a small number of retina stem cells during the fetal development of chickens.

Above all, he has examined how one of the retina’s specialized cell types, so-called horizontal cells, are formed and reach maturity. Their task is to receive and integrate information from a large number of photoreceptors, and there are at least two functionally different types.

“We have characterized the molecular development of these different horizontal cell types in order to better understand how the nervous system is formed,” explains Per-Henrik Edqvist.

He shows that the different types take on their determined role at a very early stage in development, which conflicts with certain conventional models of the development of the retina. What’s more, they do not develop simultaneously but rather one after the other, and in their development they undergo a highly unexpected cell migration from their birth site to their ultimate position in the retina.

“The fact that they migrate at different times toward or away from signals that can influence their continued development may be the mechanism that governs them in different developmental directions,” says Per-Henrik Edqvist.

The dissertation enhances our knowledge of how the central nervous system is formed during fetal development, and thereby our understanding of how disturbances of the brain and ocular system can occur and be prevented.

“By understanding these mechanisms, we hope some day to be able to use stem cells to create spare parts that can replace damaged or dead nerve cells in the retina.”

Anneli Waara | alfa
Further information:
http://www.uu.se

More articles from Health and Medicine:

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

nachricht Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>