Boris Mraovic, M.D., assistant professor of anesthesiology in the Artificial Pancreas Center at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his colleagues examined records of nearly 6,500 hip or knee replacement surgery patients at Thomas Jefferson University Hospital who were admitted between 2003 and 2005. They asked what happened to patients with high blood sugar that wasn't well controlled prior to surgery.
Of these patients, 38 had very high blood glucose – more than 250 mg/dl – on the day of preoperative testing and the day of surgery. The team found that approximately 10.5 percent of the patients with high blood sugar developed a pulmonary embolism, a life-threatening condition in which blood clots travel to the lungs, after surgery, a rate that is 6.2 times greater than would be expected in the general population. The researchers report their results on October 15, 2006 at the annual meeting of the American Society of Anesthesiologists in Chicago.
"These data suggest that if an individual has high blood glucose and is coming for surgery, he or she should correct it first and probably postpone the surgery," says Dr. Mraovic.
Physicians should also be aware of these risks, he notes, and should make it a priority to be sure that patient glucose levels are under control prior to and during surgery.
Dr. Mraovic says that as many as 25 percent of all surgery patients come to the hospital with high blood sugar. Another 10 percent have raised levels due to pre-surgery stress. Deep vein thrombosis occurs in approximately two million Americans each year. Pulmonary embolism (PE), which can cause sudden death, occurs when a clot dislodges from the vein and circulates into the lungs. Each year some 600,000 patients develop PE, which causes or contributes to as many as 200,000 deaths annually in the U.S.
He notes that recent studies have begun to show connections between increased blood sugar and a greater risk of dying or of medical complications for hospital patients in intensive care or cardiac care units. Tightening glucose control dramatically cuts those risks, as well as reduces hospital stays.
Because the current study was retrospective, Dr. Mraovic says, drawing firm conclusions from the results can be difficult. The findings need to be confirmed in a randomized, prospective trial.
He would like to next find out whether controlling blood sugar before and during surgery could actually result in a lower risk of blood clots and pulmonary embolism. He also would like to explore some of the potential physiological mechanisms related to increased blood glucose and blood clotting.
Steve Benowitz | EurekAlert!
NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)
High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses