The Ad5-TRAIL gene therapy for prostate cancer research trial is a Phase I study designed to test the optimal dosage at which the therapeutic agent can safely be given to patients.
The clinical study is being co-led by Thomas Griffith, Ph.D., an associate professor in the Department of Urology, and Richard Williams, M.D., the Rubin H. Flocks Chair in Urology and professor and head of the UI Department of Urology.
"This is the first use of this type of anti-cancer agent which was developed at the University of Iowa. This new gene therapy may help us successfully manage patients with high-risk prostate cancer," Griffith said. "Ideally, we hope to be able to say at the conclusion of this trial that this novel agent is safe and performs as intended by causing the death of prostate tumor cells with no harm to normal cells. However, being at the initial stages of the trial, it is premature to make any claims until the data is analyzed."
Researchers injected the investigational therapeutic into the cancerous prostates of three patients. Then, following a 10-day waiting period, surgeons removed the prostates and are evaluating the results.
"The preliminary results appear promising," Williams said. "The patients have tolerated the treatment without any serious side effects, which we hope will permit us to proceed with the research process."
Investigators plan to enroll up to 12 additional participants in the Phase I segment of the study.
"While the vaccine is not intended to be curative at this stage, the role of the research participants is critically important to what is truly a team effort. Without the involvement of our patients, we could not succeed," said Timothy Ratliff, Ph.D., the Anderson-Hebbeln Professor of Urology, and co-investigator in the study.
Funding for this trial has come from the following sources or agencies:
-- Roy J. Carver Charitable Trust - funds for preparing the clinical-grade virus;
-- Alliance for Cancer Gene Therapy - preclinical studies;
-- Holden Comprehensive Cancer Center at the UI - preclinical studies and protocol development;
-- U.S. Department of Defense - protocol development and clinical trial;
-- National Institutes of Health - clinical trial and Gelfoam studies.
To create the vaccine, the team used a virus that causes the common cold, but which has been engineered to be non-replicative in humans. The disabled virus, known as an adenovirus, can then be used as a vector, or carrier, of other genes that researchers insert into the virus.
The UI researchers say it will take several years before the treatment could be approved and come into general use, even if it is shown to be effective.
Other UI investigators involved in the study include:
Fadi Joudi, M.D.; Badrinath R. Konety, M.D.; Michael B. Cohen, M.D.; Brian K. Link, M.D.; Barbara Ziegler, program assistant; Tammy Madsen, physician assistant; and Carlene A. Etscheidt, clinical research coordinator.
Prostate cancer is the third-leading cause of death among men in the United States. African-American males are at a higher risk for the disease than other men.
Holden Comprehensive Cancer Center at the UI is Iowa's only National Cancer Institute (NCI)-designated comprehensive cancer center. NCI-designated comprehensive cancer centers are recognized as the leaders in developing new approaches to cancer prevention and cancer care, conducting leading edge research and educating the public about cancer.
STORY SOURCE: Joint Office for Marketing and Communications, University of Iowa Health Care, 200 Hawkins Drive, Room E110 GH, Iowa City, Iowa 52242-1009
MEDIA CONTACT: Tom Moore, 319-356-3945, firstname.lastname@example.org.
Tom Moore | EurekAlert!
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences