The multicenter team of researchers, led by Anne McTiernan, M.D., Ph.D., of Fred Hutchinson Cancer Research Center, found that women who had the lowest body-mass index, or BMI, and the highest physical-activity levels had the lowest levels of circulating estrogens, sex hormones that can fuel breast-cancer growth.
Specifically, they found a significant decrease in the two most common, biologically active forms of estrogen, estrone and estradiol, among the most active, lean women studied. The researchers found that women with high BMI and low physical-activity had mean estrogen concentrations that were 50 percent to 100 percent higher than that of women with low BMI and high activity levels.
"Women with high levels of estrogens have a two-to-four-times-higher risk of breast cancer than women with very low levels," said McTiernan, a member of the Hutchinson Center's Public Health Sciences Division and co-investigator of the Women's Health Initiative Clinical Coordinating Center, which is based at the Center. "If a woman can keep her own natural estrogens lower after menopause, it is probably going to be beneficial in terms of reducing her risk of breast cancer."
The study, based on a random sample of 267 postmenopausal women nationwide selected from the WHI Dietary Modification Trial, is the first of its kind to examine the dual impact of body weight and physical activity on levels of various circulating sex hormones thought to impact cancer risk.
"Other studies have looked at the impact of body weight by itself or physical activity by itself but this is the first to look at both together regarding their influence on hormone levels," McTiernan said. "This gives us a new understanding that combining weight control with high levels of physical activity is necessary for keeping estrogens at a healthy level in postmenopausal women." Exercising vigorously for 30 to 60 minutes a day, five days a week would achieve this benefit, McTiernan said.
Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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