In addition to its known ability to block an enzyme called cyclooxygenase (COX), aspirin also reduces the formation of blood vessels that fuel developing tumors, it is reported in the current (October) edition of a leading scientific journal.
Without new blood vessels - formed through a process called angiogenesis - tumors cannot grow beyond the size of a pea. With this information, researchers can pursue new lines of investigation that could ultimately yield an entirely new type of cancer-fighting drug.
In the study, Dr Helen Arthur and colleagues at Newcastle University Medical School show that salicylate, an ancient remedy found in plants and closely related to aspirin, also reduces the formation of new blood vessels, an important part of tumor development.
The findings, which appear in the October 2006 issue of The Journal of the Federation of American Societies for Experimental Biology (FASEB), provides important clues to how aspirin works in cancer and in inflammation.
'Aspirin has always been touted as a wonder drug,' said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, 'and this study shows that we are still learning about the many actions of this amazing drug.'
Dr Arthur said: 'We know from previous studies that low doses of aspirin taken over long periods can reduce the risk of cancer - by as much as 50 per cent in the case of bowel cancer.
'Aspirin seems to work against tumour formation in several ways, one of which is to restrict the blood supply. Tumours attract a blood supply by releasing growth factors that cause nearby blood vessels to grow into the tumour.
'We conducted experiments which involved applying various doses of aspirin to cells, which normally line the inside of blood vessels.
'Our experiments showed that low doses of aspirin had an effect on these cells which tended to cancel out the effect of the growth factors from the tumours.
She added: 'High doses of aspirin are toxic and we would like to stress that anyone suffering from cancer should not take aspirin unless they are advised to do so by a doctor.'
Dr Helen Arthur | alfa
Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München
Improving memory with magnets
28.03.2017 | McGill University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Health and Medicine
29.03.2017 | Earth Sciences
29.03.2017 | Trade Fair News