Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early detection of carcinoma of uterine cervix

04.10.2006
Detection of carcinoma of uterine cervix at the very early stage is possible by the telomerase enzyme activity.

This conclusion was made by specialists of the Lomonosov Moscow State University and the N.N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, after they have investigated several dozens of this tumor samples caused by papilloma viruses.

Telomerase is the enzyme that enables the cell division for unlimited number of times. Civilized cells are capable to undergo no more than 30 to 50 divisions, and they die after that. This is due to the fact that each chromosome’s ends represent recurrent sequences (telomers). With each division, the telomer length is decreases, and when it reaches the critical value, cells lose the ability for further division. However, the telomerase enzyme works in some cells, lengthening chromosome ends and allowing the cells to divide infinitely. The telomerase acts like this in stem cells and in germ line cells, in immortal cell lines cultivated in laboratories, as well as in the majority of cancer cells (80 to 90 percent). The enzyme activity could serve as a universl marker for cancer early detection, if it were not one “but”. Some types of malignant cells maintain a constant length of their telomer by means of a different mechanism, without telomerase participation. Therefore, the question whether the telomerase enzyme can be used as an “ alarm signal” should be resolves separately for each type of tumor.

The researchers used as investigation matter 28 tumor samples received from cervical carcinoma patients. All cases were caused by papilloma viruses. The major part of tumors were at early stages but some of them had metastases in lymph nodes. For reference, the researchers used non-cancerous growth cervical tumor.

The researchers discovered telomerase activity in all cancerous growth samples, even at the earliest stages. In the non-cancerous tumor sample, telomerase activity is practically absent. Consequently, cancer cells of this type provide for their “immortality” particularly with the help of telomerase. The researchers did not discover distinctions between cervical tumors from patients with metastases and without them, therefore, it will be impossible to determine the stage of disease by telomerase activity. But it is quite expedient to use the enzyme’s activity as a tumor marker to “catch” it at an early stage.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>