The project is to recruit the sufferers over a six-month period and to carry out the project jointly between the Cellular Therapy Area and the Department of Urology at the University Hospital of Navarra.
Amongst adult women, incontinence is largely due to the loss of muscular mass of the sphincter, recoverable by injecting this sphincter zone with the patient’s own muscle cells (myoblasts) with the objective of regenerating this muscle, enhancing its contractility and reducing incontinence.
The knowledge of this technique worldwide is confined to less than 200 patients: half a dozen in Canada and about 180 in Austria. The initial idea is the same, although there are differences in how the cells are obtained and in their processing.
The treatment of cystoceles (prolapses of the bladder) is currently undertaken using meshes that act to reinforce the original tissues. These are usually synthetic or of natural (biological) origin, but other, hybrid materials, are being worked with.
Thus, with this collaboration between the Department of Urology and the Cellular Therapy Area in adult stem cell therapy for the treatment of urinary incontinence and prolapses of the pelvic organs, there is another line of research: the use of biological meshes as a support or as “scaffolding” onto which cells are infiltrated so that the myofibroblasts might grow. It is intuitive to believe that the mesh becomes covered with the fibromuscular cells themselves, and that they penetrate the mesh. It is this that is really the reinforcement; the mesh is but a supportive scaffolding rather than an end in itself.
Cooperating in carrying out this project is the BARD company, which manufactures and markets biological meshes. A number of in vitro studies and experiments with animals will be undertaken in order to favour cell growth on the biological meshes and the effect of these with a number of agents. Then they will be implanted in model experimental animals to examine their capacity to integrate into the tissue and carry out the function of support.
Irati Kortabitarte | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy