In a special issue of the Journal of Alzheimer's Disease published this month, ten contributions from worldwide experts in the field examine possible linkages between folate and homocysteine and Alzheimer's disease.
In the lead article Guest Editor Thomas Shea, Professor and Director of the Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts Lowell, suggests “Alzheimer’s disease has a multifactoral etiology, encompassing genetic and nutritional risk factors, and no single risk factor can account for all cases.…A genetic predisposition may remain latent pending an age-related critical decline in nutrition. This has confounded the linkage of nutrition to Alzheimer’s disease, since contributing nutritional deficiencies may remain undetected, and, even if considered, may not receive sufficient attention if they are benign in isolation.”
Andrew McCaddon from the Wales College of Medicine contributes some historical perspective on homocysteine and folate levels and the development of dementia, including some discussion of the potential for reversing such declines.
Aron M. Troen and colleagues from Tufts University write of their studies of mice fed diets to create excess homocysteine levels and then tested for cognitive functions. Sudha Seshadri discusses whether elevated homocysteine levels is a risk factor for dementia or merely a risk marker for some underlying process. Amy Chan and Thomas B. Shea then examine the connection between dietary deficiencies of folate and Vitamin E and the development of neurofibrillary tangles of tau protein, a hallmark of Alzheimer's disease.
Moving on to possible therapies, Sigfrido Scarpa and colleagues at the University of Rome investigated S-adenosylmethionine (SAM) metabolism in cell cultures, which might be used to interfere with amyloid-ß overproduction, another characteristic of AD. In a second contribution from that institution, Rosaria A. Cavallaro and co-workers looked at whether SAM administration influences gene expression in the brain.
Flaubert Tchantchou of the University of Maryland School of Pharmacy discusses the various metabolic processes involved in homocysteine regulation and the various consequences of folate deficiency.
Folate is one of the B vitamins. Martha Clare Morris and colleagues at the Rush University Medical Center expand on the possible role of all of the B vitamins in cognitive decline and comment on the potential benefits and harms of vitamin supplementation. In another contribution, Morris and coworkers report on a prospective cohort study of 1041 patients where dietary folate, B-12 and B-6 levels were not associated with the development of Alzheimer's disease.SPECIAL ISSUE: FOLATE AND HOMOCYSTEINE IN ALZHEIMERS DISEASE
Aron M. Troen, Barbara Shukitt-Hale, Wei-Hsun Chao, Bina Albuquerque, Donald E. Smith, Jacob Selhub, Jacob RosenbergElevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease?
Sudha SeshadriDietary and genetically-induced oxidative stress alter tau phosphorylation: Influence of folate and apolipoprotein E deficiency
Amy Chan and Thomas B. SheaGene silencing through methylation: An epigenetic intervention on Alzheimer disease
Sigfrido Scarpa, Rosaria A. Cavallaro, Fabrizio D'Anselmi, Andrea FusoThe effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis
Rosaria A. Cavallaro, Andrea Fuso, Fabrizio D'Anselmi, Laura Seminara, Sigfrido ScarpaHomocysteine metabolism and various consequences of folate deficiency
Martha Clare Morris, Denis A. Evans, Julie A. Schneider, Christine C. Tangney, Julia L. Bienias, Neelum T. AggarwalSelected Abstracts From the "Wellness For Persons With Dementia" Symposium
Astrid Engelen | alfa
Research offers clues for improved influenza vaccine design
09.04.2018 | NIH/National Institute of Allergy and Infectious Diseases
Injecting gene cocktail into mouse pancreas leads to humanlike tumors
06.04.2018 | University of Texas Health Science Center at San Antonio
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.
Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
19.04.2018 | Materials Sciences
19.04.2018 | Physics and Astronomy
19.04.2018 | Physics and Astronomy