Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Coronary surgery - keeping the way clear

20.09.2006
EUREKA project E! 3147 DRUG ELUTING STENT has developed a new generation of stent – a wire mesh tube.

This medical device keeps the coronary artery open while controlling the dose of medication and preventing blockage and excessive scaring. Coating the stent in biodegradable polymer containing the exact dose of medication ensures its total release and avoids potentially toxic drug retention. With heart disease and blocked coronary arteries among the major killers in the western world, this project hopes to pave the way for more precise drug delivery and increase success levels in heart surgery.

Ensuring blood supply to the heart, through the coronary artery, is essential to keep it working. However, the coronary artery is particularly prone to narrowing, causing a restricted blood flow and leading to angina or heart attacks. By inserting a wire mesh tube collapsed to a narrow diameter (the stent) into the narrow part of the artery, and inflating a balloon catheter inside, the artery is successfully held open. This procedure often causes damage to the artery wall; scar tissue forms around the stent and blocks the artery. The current technology consists in coating the stent with a biodegradable polymer bound with a drug to control this unwanted cell growth.

Less drug needed

The major problem with current drug eluting stents is that 85% of the drug, which is very toxic, remains in the coronary vessel for the rest of the patient’s life because it is bound in the polymer. To remedy this problem, the participants in the project developed a bio-absorbable polymer which is completely absorbed after about three weeks. This means it is possible to use a much smaller dose of drug, allowing for complete assimilation and leaving none unused in the stent. Blue Medical, a project participant from the Netherlands, has developed the optimum biopolymer and two drugs which will regulate excessive cell growth with much lower toxicity than is currently needed. Extensive testing has led to creating a uniform, reproducible and accurate biopolymer coating for the metal stent.

Blue Medical Devices focused on the drugs development, their interaction with the polymer and designing and validating the dosage as well as the elution rates and determining the effect of bio-absorption. Their partner, Creganna Medical Devices from Ireland, developed the process of applying the biodegradable polymer to the metal surface of the stent, with or without a drug component.

Both partners foresee a strong future for the product, which should be available in mid-2007. The projected market could reach 30% of the total stent market outside the US; worth €800m. Blue Medical has increased its workforce from 30 to 50 in two years and expects to employ 150 people by 2008. “As well as substantial financial benefit, participating in a EUREKA project has given the project a much higher profile and status, enabling strong international working relationships to be developed,” believes Ronald Horvers, project coordinator at Blue Medical Devices.

Sally Horspool | alfa
Further information:
http://www.eureka.be/drugelutingstent

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>