Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Coronary surgery - keeping the way clear

20.09.2006
EUREKA project E! 3147 DRUG ELUTING STENT has developed a new generation of stent – a wire mesh tube.

This medical device keeps the coronary artery open while controlling the dose of medication and preventing blockage and excessive scaring. Coating the stent in biodegradable polymer containing the exact dose of medication ensures its total release and avoids potentially toxic drug retention. With heart disease and blocked coronary arteries among the major killers in the western world, this project hopes to pave the way for more precise drug delivery and increase success levels in heart surgery.

Ensuring blood supply to the heart, through the coronary artery, is essential to keep it working. However, the coronary artery is particularly prone to narrowing, causing a restricted blood flow and leading to angina or heart attacks. By inserting a wire mesh tube collapsed to a narrow diameter (the stent) into the narrow part of the artery, and inflating a balloon catheter inside, the artery is successfully held open. This procedure often causes damage to the artery wall; scar tissue forms around the stent and blocks the artery. The current technology consists in coating the stent with a biodegradable polymer bound with a drug to control this unwanted cell growth.

Less drug needed

The major problem with current drug eluting stents is that 85% of the drug, which is very toxic, remains in the coronary vessel for the rest of the patient’s life because it is bound in the polymer. To remedy this problem, the participants in the project developed a bio-absorbable polymer which is completely absorbed after about three weeks. This means it is possible to use a much smaller dose of drug, allowing for complete assimilation and leaving none unused in the stent. Blue Medical, a project participant from the Netherlands, has developed the optimum biopolymer and two drugs which will regulate excessive cell growth with much lower toxicity than is currently needed. Extensive testing has led to creating a uniform, reproducible and accurate biopolymer coating for the metal stent.

Blue Medical Devices focused on the drugs development, their interaction with the polymer and designing and validating the dosage as well as the elution rates and determining the effect of bio-absorption. Their partner, Creganna Medical Devices from Ireland, developed the process of applying the biodegradable polymer to the metal surface of the stent, with or without a drug component.

Both partners foresee a strong future for the product, which should be available in mid-2007. The projected market could reach 30% of the total stent market outside the US; worth €800m. Blue Medical has increased its workforce from 30 to 50 in two years and expects to employ 150 people by 2008. “As well as substantial financial benefit, participating in a EUREKA project has given the project a much higher profile and status, enabling strong international working relationships to be developed,” believes Ronald Horvers, project coordinator at Blue Medical Devices.

Sally Horspool | alfa
Further information:
http://www.eureka.be/drugelutingstent

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>