Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Risks of gastrointestinal ulcers linked to aspirin use might outweigh its benefits for the heart in certain patients

20.09.2006
Doctors should consider whether patients are at high risk of stomach ulcers before prescribing aspirin treatment.

A study published today in the open access journal BMC Medicine reveals that low-dose aspirin treatment may be responsible for one extra case of gastrointestinal complications, which include ulcer bleeding or perforation, in every 50 aspirin users per year in susceptible groups, such as older men with a history of peptic ulcer. The authors conclude that for some patients taking aspirin to reduce their risk of heart attack, the risk of gastrointestinal complications might outweigh the cardioprotective effects of the drug.

Sonia Hernández-Díaz and Luis García Rodríguez analysed two anonymous databases of patient information, the General Practice Research Database in the UK and the Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria in Spain, to characterise patients taking low-dose aspirin as a preventive measure against heart attack, in terms of major gastrointestinal risk factors. Risk factors for upper gastrointestinal tract complications include advanced age, male sex, prior ulcer history and use of other non-steroidal anti-inflammatory drugs (NSAIDs). The researchers then estimated the excess gastrointestinal risk caused by aspirin use in patients with and without these risk factors.

Hernández-Díaz and García Rodríguez find that 88% of aspirin users are over 60 and that 52-54% of them are male. From 3.8% to 5.9% of them have a history of gastrointestinal ulcer. Across all risk groups, aspirin use is responsible for an extra 5-6 cases of upper gastrointestinal tract complications per 1,000 aspirin users per year. This excess risk is larger in populations that are at high risk of gastrointestinal complications, such as older men or patients with a history of peptic ulcer. The authors estimate that aspirin use might be responsible for 20 extra cases per 1,000 aspirin users per year in men older than 70 with a past history of peptic ulcer. On the other hand, the excess risk is smaller in populations that are at low risk of gastrointestinal complications.

Juliette Savin | alfa
Further information:
http://www.biomedcentral.com

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>