"This line of research is important because many physicians and other experts in heart disease and cholesterol are familiar with the benefits of statins and other cholesterol drugs, but are unfamiliar with the adverse experiences with these drugs that many people have reported – such as effects on muscle pain or weakness, memory and thinking, or mood," said Beatrice A. Golomb, M.D., Ph.D., Associate Professor of Medicine, and head of the UCSD Statin Study.
A statin is any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol. Statin cholesterol-lowering drugs are among the most prescribed drugs in the United States. According to Consumer Reports, two such drugs – atorvastatin (Lipitor) and simvastatin (Zocor) – were #1 and #2 best-selling drugs in the country in 2004, with 75 million prescriptions for Lipitor alone. Although pharmaceutical companies report that side effects of statin drugs are rare, there are some patients who experience serious consequences of taking these drugs.
"We received many calls from patients in the community experiencing side effects, and wanting answers about what to expect. We developed this web site as a tool to gather information on side effects, and to help answer these questions," said Golomb.
The site will provide access to a broad group of people, facilitating the opportunity for patients to confidentially share information about their experience, said Golomb, who adds that a comprehensive understanding of the impact of cholesterol-lowering medications, including statins, has not been undertaken. The site also provides information on statin use, including what users can expect and ways in which they can minimize health risks.
Golomb has been actively researching the effects of statin medications for the past seven years. She and the research team at UCSD School of Medicine are currently completing an NIH-funded study of 1,000 subjects to evaluate the effects of statin drugs on cognition, behavior and serotonin biochemistry. According to Golomb, among people who have contacted the UCSD Statin Study to report adverse effects, nearly 60% of patients reported muscle weakness or fatigue, and about half reported cognitive problems.
"We believe it is important to understand the full spectrum of effects, both beneficial and adverse," said Golomb. "Our work is geared toward expanding knowledge of the impact of statins in order to better inform the public and the medical community. By filling out the web site survey, statin patients can help us to help others with the same concerns."
Scientists develop tiny tooth-mounted sensors that can track what you eat
22.03.2018 | Tufts University
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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22.03.2018 | Earth Sciences