Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New project in Edinburgh could help tens of thousands of prostate cancer patients in future

19.09.2006
A special project to identify whether a molecule known to be responsible for the muscle-wasting condition experienced by over half of all patients with advanced prostate cancer is in fact associated with the survival of the cancer itself, gets underway in Edinburgh this week.

Dr Jim Ross, who comes from Kilmarnock, has been awarded a grant from the Association for International Cancer Research (AICR) to investigate the role of Proteolysis Inducing Factor - or PIF - in prostate cancer spread following the discovery by US scientists of a link with advanced breast cancer.

Dr Ross of the Tissue Injury and Repair Group at the University of Edinburgh’s Medical School explains: "Over half of all patients with advanced prostate cancer will develop cancer cachexia which is the name of the syndrome of weight loss, loss of appetite and anaemia associated with advanced malignancy.”

"The weight loss of cancer cachexia is associated with a lower survival rate and poorer response to chemotherapy and radiotherapy. And, with even a five per cent weight loss it leads to a worse prognosis than for a cancer patient of normal weight."

Recently, scientists have discovered that starving cancer cells of oxygen will cause many tumour cells to perish. However, paradoxically, the hardiest of prostate cancer cells will survive these harsh conditions and flourish. It is now thought that low oxygen levels allow the selection of prostate cancer cells which become more aggressive and eventually lead to spread of the cancer to other sites, rendering the disease incurable.

Adds Dr Ross: " PIF has also been identified as permitting survival of breast cancer cells when they are grown in the low oxygen conditions present in a tumour and may allow these cancer cells to survive, divide and spread. Breast cancers not able to produce PIF are less likely to be able to survive these conditions and are less aggressive. Recently, PIF has also been found in some prostate cancers and our study will investigate its role in allowing the survival of prostate cancer cells in an oxygen-reduced environment."

According to Dr Mark Matfield, AICR's scientific adviser if PIF is found to support survival of prostate cancer cells then it would be a good target for future treatment of a cancer which currently claims the lives of more than 10,000 UK men every year.

"Dr Ross and his colleagues, Professor Kenneth Fearon and Drs Grant Stewart and Fouad Habib, will study improved methods of detecting PIF in cells and bodily secretions such as urine. The hope is to be able to produce a new detection method and to target these patients with novel drugs to treat weight-loss associated with cancer."

Derek Napier, AICR's Chief Executive says the three-year grant, worth more than £100,000, has been given in line with the charity's policy of funding the most novel approaches to research worldwide. “This is an exciting project set to tackle one of the most challenging problems facing cancer researchers. However, these are early days and it could be some time before it is known whether it will lead to effective drugs to help treat cancer patients,” he cautions.

Susan Osborne | alfa
Further information:
http://www.aicr.org.uk

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>