Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

“Allergy cells” can aggravate cancer and psoriasis

11.09.2006
The body’s mast cells are mainly associated with allergic reaction in the way they release histamine and other inflammatory substances. However, researchers at Karolinska Institutet have now demonstrated how the mast cells can also contribute to diseases like psoriasis and cancer.

Mast cells are most known for their association with allergic reactions, as they act like microscopic “bombs” to trigger the release of a number of substances that give rise to the classic allergic symptoms, such as swelling, congestion and itching. The explosive reactions are activated when an allergen (such as pollen particles) binds to receptors on the surface of the mast cell, which then opens and secretes part of its contents.

In the past few years it has emerged that mast cells, which are a type of immune cell, are probably also involved in the development of a number of other diseases, like atopical eczema, psoriasis, and the Hodgkins lymphoma cancer type. These diseases are characterised by chronic inflammations and an increase in the number of mast cells. However, the mechanisms behind this are relatively unknown.

Associate professor Gunner Nilsson at Karolinska Institutet and his research group have now found a possible explanation for the link between mast cells and several non-allergic diseases. The study, which is presented online by The Journal of Clinical Investigation, shows that mast cells can be activated in a previously unknown way that might lead to chronic inflammation.

“These new findings contribute to our understanding of the part played by the mast cell in atopical eczema, psoriasis and Hodgkins Lymphoma,” says Mr Nilsson. “We hope that our research will make it possible for scientists to develop new forms of therapy for the mast cell-related diseases.”

The group discovered that the CD30 protein, which is found on the surface of the immune systems T-lymphocytes amongst other places, can stimulate mast cells to release proteins that regulate the recruitment of inflammatory cells. Since it is already known that levels of CD30 are higher in people with psoriasis or atopical eczema and with Hodgkins lymphoma, the results can explain how the mast cells are activated and how they aggravate inflammation in these diseases.

Katarina Sternudd | alfa
Further information:
http://www.jci.org
http://www.ki.se

More articles from Health and Medicine:

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>