The new research by a Warwick Medical School team, Dr Harpal Randeva, Dr Paul O'Hare & Dr Dimitris Grammatopoulos; Consultant Endocrinologists and Mr Manu Vatish, Consultant Obstetrician, focussed on the profound alterations in the hormonal metabolism of pregnant women and the metabolic signals between mother and fetus. They particularly looked at a key signalling molecule, mainly produced by fat cells, called adiponectin. This is known to have anti-diabetic properties as well as anti-inflammatory and anti-atherogenic actions (it prevents blood clotting which can block arteries). They also closely examined levels of leptin which plays an important role in regulating energy balance and rises during pregnancy.
Given the high perinatal mortality associated with Type 1 diabetes, the researchers investigated adiponectin and leptin levels during both normal and Type 1 diabetic pregnancies. They measured both groups at 20 and 30 weeks into the pregnancy, and after giving birth.
Their novel observations showed that adiponectin levels were higher in pregnant women with type 1 diabetes at all stages of the study compared with the non-diabetic patients. Leptin levels were not different. Furthermore, they have identified adiponectin receptors on the human placenta and detected that the placenta also produces adiponectin. The researchers believe that the fetus produces adiponectin to protect itself from an adverse environment.
This is of vital importance since altered adiponectin levels could now be used to help give effective and early monitoring of the risks faced by women with type 1 diabetes and identify babies who are at risk.
The researchers are now looking for support to extend their studies to develop biological markers for at risk pregnancies. They particularly wish to extend their studies to examine pregnant women with type 2 diabetes and also to pregnant women who are obese (since recent data from the British Journal of Obstetrics & Gynaecology suggests that obese women are at double the risk of stillbirth). The researchers are looking for support to conduct this research and to develop biological markers for at risk pregnancies.
Peter Dunn | alfa
Cardiac diseases: when less is more
30.03.2017 | Universitätsspital Bern
TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
30.03.2017 | Physics and Astronomy
30.03.2017 | Studies and Analyses
30.03.2017 | Life Sciences