Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research could help women facing high risk of stillbirth

06.09.2006
The risk of stillbirth is particularly high for women with Type 1 or Type 2 diabetes who suffer four times as many stillbirths as non-diabetic women. The tools currently available to monitor such risks are limited and give results only at late stages of pregnancy. Now research by Warwick Medical School at the University of Warwick is identifying new methods of early & accurate monitoring of the risks faced by such women.

The new research by a Warwick Medical School team, Dr Harpal Randeva, Dr Paul O'Hare & Dr Dimitris Grammatopoulos; Consultant Endocrinologists and Mr Manu Vatish, Consultant Obstetrician, focussed on the profound alterations in the hormonal metabolism of pregnant women and the metabolic signals between mother and fetus. They particularly looked at a key signalling molecule, mainly produced by fat cells, called adiponectin. This is known to have anti-diabetic properties as well as anti-inflammatory and anti-atherogenic actions (it prevents blood clotting which can block arteries). They also closely examined levels of leptin which plays an important role in regulating energy balance and rises during pregnancy.

Given the high perinatal mortality associated with Type 1 diabetes, the researchers investigated adiponectin and leptin levels during both normal and Type 1 diabetic pregnancies. They measured both groups at 20 and 30 weeks into the pregnancy, and after giving birth.

Their novel observations showed that adiponectin levels were higher in pregnant women with type 1 diabetes at all stages of the study compared with the non-diabetic patients. Leptin levels were not different. Furthermore, they have identified adiponectin receptors on the human placenta and detected that the placenta also produces adiponectin. The researchers believe that the fetus produces adiponectin to protect itself from an adverse environment.

This is of vital importance since altered adiponectin levels could now be used to help give effective and early monitoring of the risks faced by women with type 1 diabetes and identify babies who are at risk.

The researchers are now looking for support to extend their studies to develop biological markers for at risk pregnancies. They particularly wish to extend their studies to examine pregnant women with type 2 diabetes and also to pregnant women who are obese (since recent data from the British Journal of Obstetrics & Gynaecology suggests that obese women are at double the risk of stillbirth). The researchers are looking for support to conduct this research and to develop biological markers for at risk pregnancies.

Peter Dunn | alfa
Further information:
http://www.warwick.ac.uk

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>