MRI scans in premature infants can predict future developmental delays

Terrie E. Inder, M.D., associate professor of pediatrics, of radiology and of neurology at Washington University School of Medicine in St. Louis, and pediatric researchers in New Zealand and Australia found that the magnetic resonance imaging (MRI) scans were able to determine abnormalities in the white matter and gray matter of the brains of very pre-term infants, those born at 30 weeks or less. Following the infants from birth to age 2, the researchers were able to grade those abnormalities to predict the risk of severe cognitive delays, psychomotor delays, cerebral palsy, or hearing or visual impairments that may be visible by age 2.

The results of the study appear in the Aug. 17 issue of the New England Journal of Medicine. The researchers studied 167 preterm infants in New Zealand and Australia and at St. Louis Children's Hospital. Inder said the findings are a breakthrough because previous technology — cranial ultrasounds — did not show the abnormalities in the infants' brains.

“With the MRI, now we can understand what's going wrong in the developing brain when the baby is born early,” Inder said. “We can use the MRI when the baby reaches full-term (40 weeks) to predict neurodevelopmental outcomes.” More than 2 percent of all live births are infants born before 32 weeks of gestation. Nationwide, the rate of premature births jumped 13 percent between 1992 and 2002, according to the March of Dimes. Recent data show that 50 percent of children born prematurely suffer some neurodevelopmental challenges, such as crawling, walking upright, running, swinging arms, and other activities that require coordination and balance. Among pre-term infants who survive, 5 percent to 15 percent have cerebral palsy, severe vision or hearing impairment or both, and 25 percent to 50 percent have cognitive, behavioral and social difficulties that require special educational resources.

The MRI scans show lesions on the infants' brains, as well as which region of the brain is affected and the severity of the risk for future developmental delays. For example, if a lesion is in the area of the brain that controls fine and gross motor skills, the risk is higher that the child will have some type of developmental delay in movement. Pediatricians would then know that the child would benefit from immediate physical therapy, Inder said.

“We can use these results to determine which baby would benefit most from physical, occupational or speech therapy,” Inder said. “We can also help prepare the parents for future challenges with learning delays and developmental disabilities.”

Media Contact

Beth Miller EurekAlert!

More Information:

http://www.wustl.edu

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors