Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers use the abdomen to deliver oxygen to assist ailing lungs

10.08.2006
Novel technique, based on an animal model, could buy needed time to heal damaged lungs and save lives

Researchers at the University of Pennsylvania School of Medicine have helped develop a technique in animal models for using the abdominal cavity to exchange gas, supplementing the function normally performed by the lungs. The goal is to provide a way to support patients who are on a mechanical ventilator, suffering from reversible lung failure, but who need extra time and support to heal -- beyond what a ventilator can provide -- in order to survive. The findings are in the August issue of Chest, the journal of the American College of Chest Physicians.

"This is an alternate, novel way to deliver oxygen to the body that does not attempt to wring more function out of an already injured lung, by using ventilator settings that can actually exacerbate the underlying lung injury. The only other alternates that can 'rest' the lung involve variations of bypass machine technology, all of which require anticoagulation," explains Joseph Friedberg, MD, Associate Professor of Surgery and principal investigator of this study. "The ability to rest the lungs and provide supplemental oxygen with a technique that appears nontoxic and does not require anticoagulants could have huge implications some day for patients suffering from potentially reversible pulmonary failure from such diseases as: anthrax, bird flu, SARS, trauma, ARDS, pulmonary embolism, pneumonia and others. Sometimes patients have a condition in which they might have a chance to recover if they could survive the most severe phase of their disease."

The system these researchers developed involves recirculating a gas-carrying liquid through the abdomen to deliver oxygen. They tested the system in adult pigs that were put to sleep and ventilated with low concentrations of oxygen to simulate lung failure. Using this technique, they observed an increase in arterial oxygen saturation (the actual percentage of blood that's carrying oxygen) from 73% to 89%. Doctors generally aim to keep the oxygen saturation of patients in the 90% range. Friedberg adds, "If this experimental finding can be translated to a critical care setting, this could be a potentially life-saving increase in oxygenation."

Friedberg's idea was inspired by a similar technique, already used for patients suffering from kidney failure -- peritoneal dialysis -- in which a catheter is placed into the abdominal cavity and the blood is cleansed by using the lining of the abdominal cavity to exchange toxins and electrolytes. Friedberg wondered if it would be possible to use the lining of the abdominal cavity for gas exchange, like a "supplemental" lung, analogous to the way it is used like a "supplemental" kidney with peritoneal dialysis. To test this idea, it was clear that a nontoxic liquid capable of dissolving large volumes of gas would be needed. Friedberg felt perfluorocarbons were well suited for this purpose.

"These were short-term proof of principle experiments performed on otherwise healthy pigs. What we found, however, was that the circuit was able to increase arterial oxygen levels by a significant degree and that the technique was simple and safe to perform in these short-term studies. We have shown that this technique has potential. The next steps would be to optimize the effect, by testing it in a lung disease model and assess long-term safety," states Friedberg.

Friedberg addresses the potential for this technology in treating critically ill patients, "I have seen patients die who might have survived if there had been some way to buy them more time for their lungs to recover. They just exceeded the ability of the ventilator to exchange enough gas through their sick lungs. Also, there is a phenomenon of ventilator-induced lung injury, a vicious cycle where the high vent settings required to support someone with lung failure actually exacerbate the underlying lung disease, requiring even more vent support. A technique like abdominal perfusion, if proven to be safe and effective, could be used to short-circuit this positive feedback loop and 'rest' the lungs, rather than enter that potentially fatal spiral."

The results of this study are in Chest (http://www.chestjournal.org/), the journal of the American College of Chest Physicians. The article is titled "Peritoneal Perfusion with Oxygenated Perfluorocarbon Augments Systemic Oxygenation." Co-authors are Shamus Carr and Joshua Collins of Penn, as well as Joshua Cantor, Atul Rao, and Thiru Lakshman of Thomas Jefferson University, Philadelphia.

Susanne Hartman | EurekAlert!
Further information:
http://www.uphs.upenn.edu
http://www.chestjournal.org/

More articles from Health and Medicine:

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>