Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Osteoarthritis Initiative Releases First Data

03.08.2006
The Osteoarthritis Initiative (OAI), a public-private partnership between the National Institutes of Health (NIH) and private industry that seeks to improve diagnosis and monitoring of osteoarthritis (OA) and foster development of new treatments, has released its first set of data.

Making this information available to researchers worldwide will expedite the pace of scientific studies and identification of biological and structural markers (biomarkers) for OA. Researchers can analyze the data to form new hypotheses for further study of OA, which is the major cause of activity limitation and disability in older people. Images, including x rays and magnetic resonance imaging scans, will also be available to researchers upon request. All data are stored with an anonymous identification number to protect the confidentiality of the participants’ information.

“Since its inception, the OAI has been a premier example of how industry, government, and academic sectors might work together to add value to biomedical research,” says NIH Director Elias A. Zerhouni, M.D. “This first data release is proof positive that with cooperation, we can achieve results that neither the government nor its private partners is able to reach alone.”

Over the next five years, the OAI will provide an unparalleled, state-of-the-art longitudinal database of images and clinical outcome information to facilitate the discovery of biomarkers for development and progression of OA. In this case, a biomarker would be a physical sign or biological substance that indicates changes in bone or cartilage.

Nearly 5,000 people at risk of developing knee OA, in the early stage of the disease or with more advanced knee OA are participating in the OAI at four centers around the United States. Participants in the research study provide biological specimens (blood, urine, and DNA); images (X rays and magnetic resonance scans); and clinical data such as dietary intake, medication use and pain, function, and general health assessments.

Data gathered from participants are available to researchers at http://www.oai.ucsf.edu. The data include symptoms; pain severity; a measure of pain, stiffness, and function known as the WOMAC OA index; walking ability; endurance; balance and strength; nutrition; and prescription medicines and alternative therapies used by the participants.

A second set of data will be released later in 2006, and a third release will take place early in 2007. Subsequent data will be released at approximately six — month intervals.

The four centers taking part in the study and their principal investigators include:

The University of Maryland School of Medicine, Baltimore; Marc Hochberg, M.D., M.P.H., in conjunction with Johns Hopkins Bayview Medical Center; Joan Bathon, M.D.
The Ohio State University, Columbus; Rebecca Jackson, M.D.
The University of Pittsburgh; C. Kent Kwoh, M.D.
Memorial Hospital of Rhode Island , Pawtucket; Charles Eaton, M.D.
The study is coordinated and the data from the study and the Web site are managed by the University of California, San Francisco. The principal investigator for the Data Coordinating Center is Michael Nevitt, Ph.D.

Today, 35 million people — 13 percent of the U.S. population — are 65 and older, and more than half of them have radiological evidence of osteoarthritis in at least one joint. By 2030, an estimated 20 percent of Americans — about 70 million people — will have passed their 65th birthday and will be at increased risk for OA.

The OAI is a public-private partnership comprised of five contracts funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Aging (NIA), Office of Research on Women’s Health (ORWH), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Center on Minority Health and Health Disparities (NCMHD) and National Center for Complementary and Alternative Medicine (NCCAM), all part of the Department of Health and Human Services’ National Institutes of Health.Private funding partners include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer Inc. Private-sector funding for the OAI is managed by the Foundation for the National Institutes of Health.

The mission of the NIAMS is to support research into the causes, treatment and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases. For more information about NIAMS, call the information clearinghouse at (301) 495-4484 or (877) 22-NIAMS (free call) or visit the NIAMS Web site at http://www.niams.nih.gov. Information on bone and its disorders can be obtained from the NIH Osteoporosis and Related Bone Diseases ~ National Resource Center; Phone (toll free) 800-624-BONE (2663) or visit http://www.osteo.org.

The NIA leads the Federal Government effort conducting and supporting research on the biomedical and social and behavioral aspects of aging and the problems of older people. For more information on aging and aging-related research, please visit the NIA Web site at www.nia.nih.gov. The public may also call for publications at 1-800-222-2225, the toll-free number for the National Institute on Aging Information Center.

The Foundation for the National Institutes of Health was established by the United States Congress to support the mission of the National Institutes of Health — improving health through scientific discovery. The foundation identifies and develops opportunities for innovative public-private partnerships involving industry, academia and the philanthropic community. A nonprofit, 501(c)(3) corporation, the Foundation raises private-sector funds for a broad portfolio of unique programs that complement and enhance NIH priorities and activities. The foundation’s Web site address is http://www.fnih.org.

The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

Ray Fleming | EurekAlert!
Further information:
http://www.nih.gov

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Satellite-based Laser Measurement Technology against Climate Change

17.01.2017 | Machine Engineering

Studying fundamental particles in materials

17.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>