Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New, shorter TB treatments could advance TB control

02.08.2006
The introduction of new, shorter treatments for tuberculosis could have a dramatic effect on global efforts to reduce the number of cases and deaths from tuberculosis, according to a new study published in PLoS Medicine.

The current recommended treatment for TB is to give four or more antibiotics for at least six months (this treatment is called “DOTS” or Directly Observed Therapy Short Course--but few patients would agree that taking drugs for 6 months is indeed a "short" course). New TB treatments are currently being tested, and it looks like some of them might be effective when taken for shorter periods. Joshua Salomon (Harvard School of Public Health) and colleagues used a mathematical model to predict what would happen if, instead of having to give a 6-month course, TB could be cured with just a 2-month course of antibiotics.

In Salomon and colleagues’ model, a 2-month course led to a quicker fall in the number of new cases of TB each year compared with a 6-month course. Patients who fail to finish a course of treatment can infect others, and it is less likely for patients to drop out of a 2-month course than a 6-month course.

The researchers applied their model to South-East Asia, a region where DOTS is being scaled up and where one-third of all new TB cases occur. They found that even if DOTS is scaled up as planned, a 2-month drug course would still reduce new TB cases and deaths much quicker than a 6-month course.

If, for example, a 2-month drug treatment were introduced by 2012, it might prevent 13% of the new cases and 19% of the TB deaths that would otherwise occur in South-East Asia between 2012 and 2030.

These benefits might be even greater if the new, shorter course treatment freed up financial and human resources to improve efforts to detect new TB cases. On the other hand, delaying its implementation until 2022 would erase three-quarters of the predicted benefits.

Like all mathematical models, this new one makes many assumptions—including the assumption that the experimental TB drugs that are currently being tested can indeed cure TB in 2 months. Nevertheless, Salomon and colleagues’ work suggests that the impact of DOTS could be improved by using shorter treatment courses.

Andrew Hyde | alfa
Further information:
http://www.plosmedicine.org

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>