Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New, shorter TB treatments could advance TB control

02.08.2006
The introduction of new, shorter treatments for tuberculosis could have a dramatic effect on global efforts to reduce the number of cases and deaths from tuberculosis, according to a new study published in PLoS Medicine.

The current recommended treatment for TB is to give four or more antibiotics for at least six months (this treatment is called “DOTS” or Directly Observed Therapy Short Course--but few patients would agree that taking drugs for 6 months is indeed a "short" course). New TB treatments are currently being tested, and it looks like some of them might be effective when taken for shorter periods. Joshua Salomon (Harvard School of Public Health) and colleagues used a mathematical model to predict what would happen if, instead of having to give a 6-month course, TB could be cured with just a 2-month course of antibiotics.

In Salomon and colleagues’ model, a 2-month course led to a quicker fall in the number of new cases of TB each year compared with a 6-month course. Patients who fail to finish a course of treatment can infect others, and it is less likely for patients to drop out of a 2-month course than a 6-month course.

The researchers applied their model to South-East Asia, a region where DOTS is being scaled up and where one-third of all new TB cases occur. They found that even if DOTS is scaled up as planned, a 2-month drug course would still reduce new TB cases and deaths much quicker than a 6-month course.

If, for example, a 2-month drug treatment were introduced by 2012, it might prevent 13% of the new cases and 19% of the TB deaths that would otherwise occur in South-East Asia between 2012 and 2030.

These benefits might be even greater if the new, shorter course treatment freed up financial and human resources to improve efforts to detect new TB cases. On the other hand, delaying its implementation until 2022 would erase three-quarters of the predicted benefits.

Like all mathematical models, this new one makes many assumptions—including the assumption that the experimental TB drugs that are currently being tested can indeed cure TB in 2 months. Nevertheless, Salomon and colleagues’ work suggests that the impact of DOTS could be improved by using shorter treatment courses.

Andrew Hyde | alfa
Further information:
http://www.plosmedicine.org

More articles from Health and Medicine:

nachricht Light beam replaces blood test during heart surgery
28.02.2017 | University of Central Florida

nachricht Cells adapt ultra-rapidly to zero gravity
28.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Scientists reach back in time to discover some of the most power-packed galaxies

28.02.2017 | Physics and Astronomy

Nano 'sandwich' offers unique properties

28.02.2017 | Materials Sciences

Light beam replaces blood test during heart surgery

28.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>