Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dundee researchers breakthrough in Cystic Fibrosis research

25.07.2006
`Fat controller’ offers key to breakthrough treatments in Cystic Fibrosis & other diseases

Researchers at the University of Dundee have uncovered key links between Cystic Fibrosis and other diseases and conditions including cancer, diabetes and obesity, findings which could open the pathway to new areas of research into understanding and treatment.

Dr Anil Mehta, who has worked in Cystic Fibrosis research for 20 years, and heads the European Union-funded Cystic Fibrosis Database based at the University, led the research which centres on the role in the body of a newly discovered hybrid protein dubbed the cellular “fat controller”.

Dr Mehta and his team have uncovered genetic pathways which lead through this fat controller and form links between Cystic Fibrosis and the other conditions.

“It has long been known that Cystic Fibrosis patients suffer significant variations in weight - they tend to be very thin and can suffer very fast weight loss when they fall ill - but we did not know why this was the case,” said Dr Mehta, a Reader in Child Health in the Department of Maternal and Child Health Sciences at the University of Dundee.

“Similarly it has been known that CF patients suffer a higher rate of cancer than normal and again we did not know why. In equal measure, almost half of these patients develop an unusual form of diabetes.

“What our research has uncovered are the genetic links, through this cellular fat controller, which we believe lead to these differences in fat metabolism and cancer. Furthermore, there are also significant links here to diabetes.”

Dr Mehta said the findings could have a major impact on research into Cystic Fibrosis and the other conditions and, subsequently, the treatment of patients..

“The implications of this are that we have opened up a whole new area of research which links all of these conditions, and from here on in researchers looking at cancer, diabetes, obesity or Cystic Fibrosis should all be working with each other and looking at what the other is doing, because it is all linked together.

“We believe that these results could have a significant impact in terms of the treatment of patients with all three diseases - Cystic Fibrosis, some forms of childhood cancer and adult onset diabetes - and, hence, their potential life expectancy.”

Dr Mehta’s research examined the relationship between three cancer-related enzymes that are associated with diabetes (NDPK), fat metabolism (AMPK) and Cystic Fibrosis (CFTR).

They found a new pathway between NDPK and AMPK which leads to variations in fat metabolism - this they have dubbed the fat controller. Additional research found that these enzymes also bind to a protein that causes cystic fibrosis, CFTR.

The new research work was carried out by Dr Mehta and a team including Research Fellow Dr Russell Crawford. A team of international collaborators in Italy, Germany, France Portugal and the USA provided further support.

Results of the research, funded by grants from the Wellcome Trust and Cystic Fibrosis Trust over the last 10 years, are published in the scientific journals ‘Cellular and Molecular Biology’ and ‘Cellular Signalling’.

In order to further debate and create greater cross-disciplinary collaboration in this area of research, the University has agreed to support Dr Mehta’s efforts to host a major international conference of experts in NDPK, AMPK and CFTR in Dundee in September 2007.

Roddy Isles | alfa
Further information:
http://www.dundee.ac.uk

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>