Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dundee researchers breakthrough in Cystic Fibrosis research

25.07.2006
`Fat controller’ offers key to breakthrough treatments in Cystic Fibrosis & other diseases

Researchers at the University of Dundee have uncovered key links between Cystic Fibrosis and other diseases and conditions including cancer, diabetes and obesity, findings which could open the pathway to new areas of research into understanding and treatment.

Dr Anil Mehta, who has worked in Cystic Fibrosis research for 20 years, and heads the European Union-funded Cystic Fibrosis Database based at the University, led the research which centres on the role in the body of a newly discovered hybrid protein dubbed the cellular “fat controller”.

Dr Mehta and his team have uncovered genetic pathways which lead through this fat controller and form links between Cystic Fibrosis and the other conditions.

“It has long been known that Cystic Fibrosis patients suffer significant variations in weight - they tend to be very thin and can suffer very fast weight loss when they fall ill - but we did not know why this was the case,” said Dr Mehta, a Reader in Child Health in the Department of Maternal and Child Health Sciences at the University of Dundee.

“Similarly it has been known that CF patients suffer a higher rate of cancer than normal and again we did not know why. In equal measure, almost half of these patients develop an unusual form of diabetes.

“What our research has uncovered are the genetic links, through this cellular fat controller, which we believe lead to these differences in fat metabolism and cancer. Furthermore, there are also significant links here to diabetes.”

Dr Mehta said the findings could have a major impact on research into Cystic Fibrosis and the other conditions and, subsequently, the treatment of patients..

“The implications of this are that we have opened up a whole new area of research which links all of these conditions, and from here on in researchers looking at cancer, diabetes, obesity or Cystic Fibrosis should all be working with each other and looking at what the other is doing, because it is all linked together.

“We believe that these results could have a significant impact in terms of the treatment of patients with all three diseases - Cystic Fibrosis, some forms of childhood cancer and adult onset diabetes - and, hence, their potential life expectancy.”

Dr Mehta’s research examined the relationship between three cancer-related enzymes that are associated with diabetes (NDPK), fat metabolism (AMPK) and Cystic Fibrosis (CFTR).

They found a new pathway between NDPK and AMPK which leads to variations in fat metabolism - this they have dubbed the fat controller. Additional research found that these enzymes also bind to a protein that causes cystic fibrosis, CFTR.

The new research work was carried out by Dr Mehta and a team including Research Fellow Dr Russell Crawford. A team of international collaborators in Italy, Germany, France Portugal and the USA provided further support.

Results of the research, funded by grants from the Wellcome Trust and Cystic Fibrosis Trust over the last 10 years, are published in the scientific journals ‘Cellular and Molecular Biology’ and ‘Cellular Signalling’.

In order to further debate and create greater cross-disciplinary collaboration in this area of research, the University has agreed to support Dr Mehta’s efforts to host a major international conference of experts in NDPK, AMPK and CFTR in Dundee in September 2007.

Roddy Isles | alfa
Further information:
http://www.dundee.ac.uk

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>