Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New cardiac MRI pinpoints closed arteries without surgery

28.06.2006
A new cardiac magnetic resonance imaging (MRI) technique can noninvasively demonstrate blockage of the coronary arteries with high diagnostic accuracy, according to a study featured in the July issue of Radiology.

Researchers at Massachusetts General Hospital (MGH) and Harvard Medical School in Boston and Beneficencia Portuguesa Hospital in Sao Paulo, Brazil compared their new imaging technique against the current diagnostic standard, coronary angiography, which is an invasive procedure. The MRI findings yielded an accuracy of 88 percent.

"We have shown that cardiac MRI can be used reliably as an alternative to other more invasive detection techniques, due to its high diagnostic accuracy, its comprehensive evaluation of cardiac function, perfusion and viability and the lack of radiation exposure," said Ricardo C. Cury, M.D., lead author and director of clinical cardiac MRI at MGH.

More than 13 million Americans have coronary artery disease (CAD); it is the number one killer in the Western hemisphere. Although coronary angiography is the current standard for detecting CAD, it is an invasive procedure that involves running a tube from a blood vessel below the heart up toward the heart itself, and then releasing contrast material into the arteries so they are visible on x-rays. There is a need for a preliminary, noninvasive way to assess the arteries to learn if such invasive investigation is required.

The authors applied a technique called stress first-pass perfusion MRI in combination with a delayed contrast-enhancement technique. This approach is different than the typical MRI sequences used to investigate the coronary arteries. With this combined technique, the researchers injected patients with a contrast material and then performed MRI at timed intervals to see if there was heart muscle ischemia attributable to coronary artery blockage and if there was damage (either tissue death or scarring) that indicated a prior heart attack.

In total, 46 patients with chest pain were enrolled in the study. All were scheduled to undergo coronary angiography. The patients were divided into two groups. The first group included 32 patients suspected of having CAD, and the second included 14 patients with prior history of heart attack and suspected new arterial lesions. The MRI protocol included assessment of the left ventricle of the heart and blood flow during medicinally induced cardiac stress and rest and myocardial damage (delayed-enhancement technique). After MRI was completed, coronary angiography was performed for comparison.

Traditional angiography demonstrated significant CAD in 30 of 46 patients (65 percent). Of these 30 patients, MRI demonstrated CAD with an accuracy of 88 percent. In patients with only one diseased vessel, the accuracy of MRI increased to 96 percent. In patients who had previously undergone bypass graft surgery, the accuracy of MRI was 90 percent.

Because of the diagnostic accuracy of this new MRI technique, it can potentially be used to enhance clinical decision-making and guide appropriate disease management; for example, when deciding whether or not to proceed with a more invasive modality like cardiac catheterization or coronary artery bypass surgery.

"In addition to diagnostic accuracy, cardiac MRI is safe," Dr. Cury added. "It can provide information about the anatomy, function, blood flow and damage that the heart has sustained. MRI can also be used to assess the blood vessels in the body."

Heather Babiar | EurekAlert!
Further information:
http://www.rsna.org

More articles from Health and Medicine:

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>