Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New cardiac MRI pinpoints closed arteries without surgery

28.06.2006
A new cardiac magnetic resonance imaging (MRI) technique can noninvasively demonstrate blockage of the coronary arteries with high diagnostic accuracy, according to a study featured in the July issue of Radiology.

Researchers at Massachusetts General Hospital (MGH) and Harvard Medical School in Boston and Beneficencia Portuguesa Hospital in Sao Paulo, Brazil compared their new imaging technique against the current diagnostic standard, coronary angiography, which is an invasive procedure. The MRI findings yielded an accuracy of 88 percent.

"We have shown that cardiac MRI can be used reliably as an alternative to other more invasive detection techniques, due to its high diagnostic accuracy, its comprehensive evaluation of cardiac function, perfusion and viability and the lack of radiation exposure," said Ricardo C. Cury, M.D., lead author and director of clinical cardiac MRI at MGH.

More than 13 million Americans have coronary artery disease (CAD); it is the number one killer in the Western hemisphere. Although coronary angiography is the current standard for detecting CAD, it is an invasive procedure that involves running a tube from a blood vessel below the heart up toward the heart itself, and then releasing contrast material into the arteries so they are visible on x-rays. There is a need for a preliminary, noninvasive way to assess the arteries to learn if such invasive investigation is required.

The authors applied a technique called stress first-pass perfusion MRI in combination with a delayed contrast-enhancement technique. This approach is different than the typical MRI sequences used to investigate the coronary arteries. With this combined technique, the researchers injected patients with a contrast material and then performed MRI at timed intervals to see if there was heart muscle ischemia attributable to coronary artery blockage and if there was damage (either tissue death or scarring) that indicated a prior heart attack.

In total, 46 patients with chest pain were enrolled in the study. All were scheduled to undergo coronary angiography. The patients were divided into two groups. The first group included 32 patients suspected of having CAD, and the second included 14 patients with prior history of heart attack and suspected new arterial lesions. The MRI protocol included assessment of the left ventricle of the heart and blood flow during medicinally induced cardiac stress and rest and myocardial damage (delayed-enhancement technique). After MRI was completed, coronary angiography was performed for comparison.

Traditional angiography demonstrated significant CAD in 30 of 46 patients (65 percent). Of these 30 patients, MRI demonstrated CAD with an accuracy of 88 percent. In patients with only one diseased vessel, the accuracy of MRI increased to 96 percent. In patients who had previously undergone bypass graft surgery, the accuracy of MRI was 90 percent.

Because of the diagnostic accuracy of this new MRI technique, it can potentially be used to enhance clinical decision-making and guide appropriate disease management; for example, when deciding whether or not to proceed with a more invasive modality like cardiac catheterization or coronary artery bypass surgery.

"In addition to diagnostic accuracy, cardiac MRI is safe," Dr. Cury added. "It can provide information about the anatomy, function, blood flow and damage that the heart has sustained. MRI can also be used to assess the blood vessels in the body."

Heather Babiar | EurekAlert!
Further information:
http://www.rsna.org

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>