Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chest X-ray exposure may increase likelihood of breast cancer

27.06.2006
An analysis of 1,600 women with BRCA 1/2 mutations suggests that exposure to chest X-rays may increase the risk of breast cancer, and that exposure before the age of 20 may be linked to particularly heightened risk. The research, conducted by a consortium of European cancer centers, was the first to analyze the impact of low-level X-ray exposure among women at genetically high risk for the disease. The study will be published online June 26 in the Journal of Clinical Oncology.

"This is one of the first studies to demonstrate that women genetically predisposed to breast cancer may be more susceptible to low-dose ionizing radiation than other women," said David E. Goldgar, PhD, a lead author of the study who was the Chief of the Genetic Epidemiology Group at the International Agency for Research on Cancer in Lyon, France, at the time the research was conducted. "If confirmed in prospective studies, young women who are members of families known to have BRCA1 or BRCA2 mutations may wish to consider alternatives to X-ray, such as MRI," Dr. Goldgar added.

Researchers analyzed questionnaire data completed by more than 1,600 women who were involved in the International BRCA 1/2 Carrier Cohort Study (IBCCS) – a collaborative European study of women who carry BRCA 1/2 mutations. While all women were carriers, not all had developed breast cancer. The questionnaire asked whether a woman had ever received a chest X-ray, whether she had received chest X-ray before age 20, after age 20, or during both periods, and how many X-rays she had been exposed to during each timeframe.

The study found that women with BRCA 1/2 mutations who reported ever having a chest X-ray were 54% more likely to develop breast cancer than women who had never undergone the procedure. In addition, women who were exposed to X-rays before age 20 had a 2.5-fold increased risk of developing the disease before age 40, compared with women who had never been exposed.

"Since BRCA proteins are integral in repairing damage to breast cells, we hypothesized that women with BRCA 1/2 mutations would be less able to repair damage caused to DNA by ionizing radiation," said Dr. Goldgar. "Our findings support this hypothesis and stress the need for prospective studies."

Investigators noted two primary limitations of the study. The first was the potential for "recall bias," meaning that women who had developed breast cancer might be more likely to remember receiving an X-ray than women who had not been diagnosed with the disease. The second was the lack of data on the specific dose and timing of radiation that was received.

"Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the IBCCS Study," Nadine Andrieu et al, INSERM Emi00-06 et Service de Biostatistique de l'Institut Curie, France.

Danielle Potuto | EurekAlert!
Further information:
http://www.asco.org
http://www.plwc.org.genetics

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>