Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chest X-ray exposure may increase likelihood of breast cancer

27.06.2006
An analysis of 1,600 women with BRCA 1/2 mutations suggests that exposure to chest X-rays may increase the risk of breast cancer, and that exposure before the age of 20 may be linked to particularly heightened risk. The research, conducted by a consortium of European cancer centers, was the first to analyze the impact of low-level X-ray exposure among women at genetically high risk for the disease. The study will be published online June 26 in the Journal of Clinical Oncology.

"This is one of the first studies to demonstrate that women genetically predisposed to breast cancer may be more susceptible to low-dose ionizing radiation than other women," said David E. Goldgar, PhD, a lead author of the study who was the Chief of the Genetic Epidemiology Group at the International Agency for Research on Cancer in Lyon, France, at the time the research was conducted. "If confirmed in prospective studies, young women who are members of families known to have BRCA1 or BRCA2 mutations may wish to consider alternatives to X-ray, such as MRI," Dr. Goldgar added.

Researchers analyzed questionnaire data completed by more than 1,600 women who were involved in the International BRCA 1/2 Carrier Cohort Study (IBCCS) – a collaborative European study of women who carry BRCA 1/2 mutations. While all women were carriers, not all had developed breast cancer. The questionnaire asked whether a woman had ever received a chest X-ray, whether she had received chest X-ray before age 20, after age 20, or during both periods, and how many X-rays she had been exposed to during each timeframe.

The study found that women with BRCA 1/2 mutations who reported ever having a chest X-ray were 54% more likely to develop breast cancer than women who had never undergone the procedure. In addition, women who were exposed to X-rays before age 20 had a 2.5-fold increased risk of developing the disease before age 40, compared with women who had never been exposed.

"Since BRCA proteins are integral in repairing damage to breast cells, we hypothesized that women with BRCA 1/2 mutations would be less able to repair damage caused to DNA by ionizing radiation," said Dr. Goldgar. "Our findings support this hypothesis and stress the need for prospective studies."

Investigators noted two primary limitations of the study. The first was the potential for "recall bias," meaning that women who had developed breast cancer might be more likely to remember receiving an X-ray than women who had not been diagnosed with the disease. The second was the lack of data on the specific dose and timing of radiation that was received.

"Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the IBCCS Study," Nadine Andrieu et al, INSERM Emi00-06 et Service de Biostatistique de l'Institut Curie, France.

Danielle Potuto | EurekAlert!
Further information:
http://www.asco.org
http://www.plwc.org.genetics

More articles from Health and Medicine:

nachricht Fast-tracking T cell therapies with immune-mimicking biomaterials
16.01.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Dengue takes low and slow approach to replication
12.01.2018 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>