Injection may prevent infertility in men receiving cancer chemotherapy
It may be possible to protect the testes of cancer patients against the loss of fertility caused by chemotherapy, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic, on Tuesday 20 June 2006. Mr. Alon Carmely from Bar-Ilan University, Ramat Gan, Israel, said that his work showed for the first time that the injection of a drug that enhances the immune system could protect the testis from the effects of paclitaxel (Taxol), a widely used chemotherapy drug.
“The effects of chemotherapy treatment on fertility are an important issue for long-term survivors of cancer who may not have started or completed a family at the time of diagnosis”, said Mr. Carmely. "AS101 is a Tellurium-based non-toxic immunomodulatory compound developed and synthesised by us. Tellurium is a transition element with similar properties to Selenium, which is also known to have many beneficial effects."
Knowing that AS101 had been shown to have chemoprotective effects in both animal and human studies, he and his team decided to investigate whether it could be used to avoid testicular damage in mice treated with Taxol. “Clinical studies had already shown that AS101 could protect against bone marrow damage and hair loss, and also sensitises the tumour to treatment”, he said.
The scientists divided the mice into four groups – Taxol only, AS101 plus Taxol, AS101 only, and a control group. After 30 days they were euthanized and their testes examined and weighed. The researchers found that a single dose of Taxol had induced significant testicular weight loss compared with the control group. An injection of AS101 a day before that of Taxol prevented the Taxol-induced weight loss.
“Tissue analysis of the testes of Taxol-injected mice showed severe atrophy and empty seminiferous tubules, where the sperm-producing cells are contained”, said Mr. Carmely. “In contrast, we saw only minimal testicular damage in the group that had previously been injected with AS101, and we could also find mature sperm. Injection of AS101 alone did not alter testicular weight or tissue analysis results.
“These results hold out much promise for fertility preservation in men undergoing cancer treatments”, he said. “We now intend to study the mechanism of protection, which is still unclear. Our work suggests that in addition to the direct damage caused by the treatment, significant testicular damage is caused by the immune reaction to it. We hope to begin clinical studies in cancer patients in the next few months.”
Mary Rice | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
Physicists in Garching observe novel quantum effect that limits the number of emitted photons.
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...