The primary objective of this first large, open-label, multicentre study of 99mTc-depreotide in Europe was to assess its diagnostic performances and compare it with fluor-18-fluoro-deoxyglucose positron emission tomography (FDG-PET), which has also been demonstrated to be efficient in the characterization of SPNs. However, PET cameras are only available in large centres.
One hundred and eighteen patients presenting with an SPN of 3 cm or smaller suspected of malignancy on CT were included in this trial. The SPECT images were acquired 1.1-4.5 h after injection of 459-770 MBq of 99mTc-depreotide. A subset of 29 patients also underwent FDG-PET imaging. The images were interpreted blindly and correlated with histopathology. 99mTc-depreotide SPECT was positive in 65 of 73 patients with a malignant lesion and negative in 30 of 45 patients with a benign lesion, resulting in a sensitivity, specificity and diagnostic accuracy of 89, 67 and 81%, respectively. In 40 patients with an SPN of 1.5 cm or smaller, the diagnostic accuracy was 88, sensitivity 75 and specificity 96%. In the subset of 29 patients who underwent both 99mTc-depreotide SPECT and FDG-PET imaging, sensitivity, specificity and diagnostic accuracy were identical for both modalities, i.e. 90, 67 and 83%, respectively.
This study confirms a satisfying performance of 99mTc-depreotide in separating malignant and benign SPNs. Since access to FDG-PET remains limited, 99mTc-depreotide is advantageous as it can be imaged with traditional nuclear medicine equipment.
Carla Holmes | alfa
A better way to measure the stiffness of cancer cells
01.03.2017 | Duke University
Humans have three times more brown body fat
01.03.2017 | Technische Universität München
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
13.02.2017 | Event News
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09.02.2017 | Event News
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01.03.2017 | Life Sciences