Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New materials developed for vascular graft

16.06.2006
Virginia Commonwealth University engineers and scientists have developed a new material that may one day help patients with damaged arteries regenerate new ones.

In the June issue of the journal Biomedical Materials, researchers reported the design and fabrication of a new material to be used for vascular grafts that in the future could ultimately be implanted in patients undergoing coronary artery graft surgery.


A scanning electron micrograph to illustrate the fibrous structure of the tube wall. The fibers are fewer than 500 nanometers in diameter, compared with the average hair shaft, which is 80,000-100,000 nanometers. Photo courtesy of Scott A. Sell/VCU.

The material is a blend of polydioxanone (PDO), a synthetic biodegradable polymer that has been used in suture materials for years, and elastin fibers, used to enhance elasticity and bioactivity of the graft. Elastin, a natural polymer, is also a major component of the arterial wall and is critical to the graft in providing a base for the cells to recognize and interact with the body. Using a technique known as electrospinning, researchers were able to manipulate the PDO-elastin composite into a conduit, or hose, for use as a small diameter vascular graft.

“We have created a vascular graft with a combination of strength and bioactivity – two things we need to maintain and regenerate the graft. Although the body is the best bioreactor for tissue regeneration or wound healing, we hope this new material will be recognized by the body as an environment conducive for regeneration,” said lead author Gary Bowlin, Ph.D., the Harris professor of biomedical engineering in the VCU School of Engineering.

According to Bowlin, the composition of the material reinforces the graft’s mechanical strength, which is critical in order to hold the blood pressure and forces while the regeneration process is taking place. The PDO-elastin blend undergoes slow degradation and causes few adverse reactions compared with previous materials used for the same purpose, he said. The purpose of the new material would be to help a patient regenerate a new artery. If it works as designed the researchers hope that at six months post-surgery, there would be no more synthetic structure left, he said.

“Regeneration needs to be timed just right, and the cells regrowth needs to be strong enough so that the patient’s own artery can take over for the synthetic material and promote regeneration,” Bowlin said. “Additionally, the synthetic material must degrade, because any foreign material in the body for an extended time is susceptible to inflammatory response or even severe infection such as staphylococcus.”

Bowlin and his colleagues are now evaluating how cells respond and interact with the different structures.

For more than 30 years, surgeons have used Teflon as a conduit or “artery” for such operations. Teflon is inert and once implanted in a patient, remains forever. However, this can lead to complications, especially in small diameter grafts in the arms, lower legs and coronary arteries. In addition, synthetic biodegradable polymers that are currently used may be adversely reactive and cause inflammatory responses, which degrades the materials faster and results in poor wound healing.

This work was supported by a grant from the American Heart Association Mid-Atlantic Affiliate.

Bowlin collaborated with Scott A. Sell, B.S.; Michael J. McClure, B.S.; Catherine P. Barnes, M.S.; and Danielle C. Knapp, M.S., all of the VCU School of Engineering’s Division of Biomedical Engineering; David G. Simpson, Ph.D., VCU Department of Anatomy and Neurobiology; and B. H. Walpoth, M.D., who is affiliated with the University Hospital in Geneva, Switzerland.

Sathya Achia-Abraham | EurekAlert!
Further information:
http://www.vcu.edu

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>