Michael Milane and colleagues (University of California, Los Angeles) analyzed suicide rates in the US general population from 1960-2002. Suicide rates fluctuated between 12.2 and 13.7 per 100,000 until 1988, and then gradually fell, with the lowest value of 10.4 per 100,000 in 2000.
The researchers also analyzed data on prescriptions of fluoxetine, which was introduced in 1988. There was an increase in the number of fluoxetine prescriptions, from about 2.5 million in 1988 to over 33 million in 2002.
Mathematical tests showed that the steady decline in suicides was statistically associated with the increased number of fluoxetine prescriptions (the more prescriptions, the fewer suicides). The authors hypothesize that fluoxetine might have saved 33,600 lives since its introduction.
Milane and colleagues acknowledge that the association they found between the fall in suicides and the introduction of fluoxetine cannot prove that the medication caused the fall. There may have been other reasons why the suicide rate declined.
Nevertheless, they argue that their findings are helpful in shedding light on the ongoing debate about whether fluoxetine (and other “SSRI antidepressants”) might trigger an increase in suicide. “Although the current issue concerning antidepressants and suicidality requires further examination,” they say, “we believe that many more lives have been saved than lost since the advent of these drugs.”
In a commentary on the new study, Bernhard Baune and Philippa Hay (James Cook University, Australia), who were not involved in the study, say that the type of study performed by Milane and colleagues cannot prove for certain “whether antidepressants do harm or good at a population level.” Nevertheless, they say that the study “does not support an association between increased suicide and increased fluoxetine prescription rates.”
Andrew Hyde | alfa
Light beam replaces blood test during heart surgery
28.02.2017 | University of Central Florida
Cells adapt ultra-rapidly to zero gravity
28.02.2017 | Universität Zürich
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
28.02.2017 | Life Sciences
28.02.2017 | Power and Electrical Engineering
28.02.2017 | Information Technology