Researchers have discovered the mechanism by which the genetic defect underlying cystic fibrosis (CF) leads to fatal bacterial colonization of the lungs. The new findings, published today in the early online edition of the Proceedings of the National Academy of Sciences, suggest that an aerosol treatment aimed at balancing pH in lung cells could be developed to stave off or delay such infections.
The most common inherited lethal disorder in Caucasians, CF stems from mutations in a gene that encodes the so-called cystic fibrosis transmembrane conductance regulator (CFTR) protein. Although scientists have known that for some time, exactly how the dysfunctional protein relates to the chronic respiratory infections that characterize the disease has remained a mystery. Enter Jens Poschet of the University of New Mexico and colleagues, who found that the defect results in the excess production of acid in lung cells. This, the team determined, prevents the cells from attaching key sugar molecules to certain proteins dotting their surfaces. The absence of those sugars, in turn, enables bacteria such as Pseudomonas aeruginosa to latch onto the cells much more easily—a prelude to infection.
Importantly, when the researchers restored normal acidity to such cells in vitro, the bacteria could no longer stick to them. "This was an exciting discovery to us, because in the test tube at least we can correct the deficiency with simple maneuvers," team member Vojo Deretic of the University of New Mexico remarks. "We already have ion pump inhibitors and antacids for treating heartburn," he adds. "If we can design similar compounds to go to the lungs, we might have a simple solution to greatly improve the health of CF patients."
Kate Wong | Scientific American
Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn
New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology
Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.
Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...
Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.
Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
30.09.2016 | Event News
29.09.2016 | Event News
28.09.2016 | Event News
30.09.2016 | Materials Sciences
30.09.2016 | Earth Sciences
30.09.2016 | Life Sciences