New research shows how topping up the levels of a hormone found in the gut could help reduce the appetite and increase activity in overweight and obese people.
The study now being pre-published online in the International Journal of Obesity shows how the team from Imperial College London gave injections of oxyntomodulin to fifteen overweight but healthy volunteers from Hammersmith Hospital, and monitored how this affected their food intake, and levels of activity.
Professor Steve Bloom, from Imperial College London, who led the research, said: “The discovery that this hormone has a double effect, increasing energy expenditure as well as reducing food intake, could be of huge importance. When most people diet, this produces a reduction in activity, which is probably an adaptive trait to conserve energy during times of famine. However this does make it especially difficult for obese individuals trying to lose weight. In contrast oxyntomodulin decreases calorific intake, but actually increases energy expenditure, making it an ideal intervention for the obese.”
Tony Stephenson | alfa
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