Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemotherapy gel may fight breast cancer and reduce breast deformity

26.04.2006


Women who undergo surgery for breast cancer followed by radiation therapy often experience breast deformities that can only be corrected through reconstructive surgery. Researchers at the McGowan Institute for Regenerative Medicine, in collaboration with bioengineers at Carnegie Mellon University, have developed a polymer-based therapy for breast cancer that could serve as an artificial tissue filler after surgery and a clinically effective therapy. Their findings, based on studies with mice, will be presented at 10:15 a.m., Tuesday, April 25 at the World Congress on Tissue Engineering and Regenerative Medicine, April 24 to 27, at the Westin Convention Center in Pittsburgh.



"Although radiation therapy is the standard treatment for breast cancer following surgery, it is expensive, time consuming and increases the cosmetic deformity caused by surgery," said Howard D. Edington, M.D., associate professor of surgery and surgical oncology at the University of Pittsburgh and faculty member at McGowan. "We sought to develop a possible alternative to radiation therapy that would not only release chemotherapy slowly to kill the cancerous cells left behind after surgery but that also would fill in the dimples and sometimes quite significant indentations that are common after breast surgery and radiation."

To test their idea, the researchers encapsulated a common breast cancer chemotherapy drug, doxorubicin, in microspheres, or beads, and then mixed them with a gelatin made of a polymer substance. Mice with breast cancer tumors were treated by inserting the gel under the skin next to the mammary gland. The researchers found that they could successfully control the delivery of chemotherapy over a period of 30 days and that the tumors were completely eradicated compared to a control group of mice that were implanted with the gel insert without chemotherapy.


"Through further research and testing, our goal is to develop this into a clinical treatment for women undergoing breast cancer surgery," said Dr. Edington who also is chief of surgery at Magee-Womens Hospital. "This treatment may help decrease the occurrences of breast deformity. With more studies under our belt, we believe this approach could eventually represent an alternative to breast radiation after surgery."

According to Dr. Edington, clinical trials on women with breast cancer will follow additional laboratory studies. A paper detailing these results will be published in the Journal of Biomedical Materials Research.

Clare Collins | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Water cooling for the Earth's crust

23.11.2017 | Earth Sciences

Nano-watch has steady hands

23.11.2017 | Physics and Astronomy

Batteries with better performance and improved safety

23.11.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>