New York University’s Alexej Jerschow, an assistant professor of chemistry, and Norbert Müller, a professor of chemistry at the University of Linz in Austria, have developed a completely non-invasive imaging method. Their work offers the benefits of magnetic resonance imaging (MRI) while eliminating patients’ exposure to irradiation and setting the stage for the creation of light, mobile MRI technology. The research, which appears in the latest issue of the Proceedings of the National Academy of Sciences (PNAS), was supported by the National Science Foundation.
MRI allows clinicians to non-invasively visualize soft tissue in the interior of the human body through the application of radiofrequency (rf) irradiation. However, the rf pulses of MRI machines deposit heat in patients and medical staff, though safety regulations that limit energy deposition have long been established. Jerschow and Müller have devised a low-energy, nuclear magnetic resonance (NMR) technique that does not require external rf-irradiation. Their technique, instead, relies on the detection of spontaneous, proton spin-noise in a tightly coupled rf-cavity.
In order to reconstruct spin-noise images that characterize MRI, the researchers used a commercial, liquid-state NMR spectrometer equipped with a cryogenically cooled probe. The sample, a phantom of four glass capillaries filled with mixtures of water and heavy water, remained at room temperature. The authors inserted the sample into a standard NMR tube and applied a magnetic field gradient to acquire spatial encoding information. They collected 30, one-dimensional images, and after applying a projection reconstruction algorithm, obtained the phantom’s two-dimensional image. Because of its low-energy deposition, Müller and Jerschow’s imaging technique may enable new application areas for magnetic resonance microscopy. Using already-developed methods, the researchers expect expansion to three-dimensional imaging to be straightforward.
James Devitt | EurekAlert!
23.03.2017 | Technische Universität München
How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Life Sciences
23.03.2017 | Power and Electrical Engineering
23.03.2017 | Earth Sciences