Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First analysis of recent disease outbreak in China

11.04.2006


First scientific analysis of Chinese outbreak of S.suis, spread from pigs to humans



Last year, there was major press coverage of an alarmingly large and deadly outbreak of Streptococcus suis disease in Sichuan province in China (see http://www.who.int/csr/don/2005_08_03/en/).

Now George Gao, Yu Wang, Jiaqi Tang, Xiaoning Wang and colleagues from the Chinese Academy of Sciences, the Chinese Center for Disease Control and Prevention, and other Chinese institutions publish the first scientific description of the outbreak in the international open-access journal PLoS Medicine.


S. suis is a pathogen with serious economic effects on the pig industry world-wide. The disease is endemic in adult pigs in most countries where pig farming is common. Infections in adult pigs are usually asymptomatic, but infant piglets that get infected through contact with colonized adult females can develop fatal sepsis.

Transmission to humans is rare and generally restricted to individuals with occupational exposure to live or dead pigs. The first human case of S. suis infection was reported in Denmark in 1968. Most of the 200 or so previously reported human cases were characterized by meningitis and septicemia; fewer than 1 in 10 infected humans died.

The recent Sichuan outbreak, in contrast, affected over 200 individuals and killed 38 of them. Besides the large number of infected individuals and the high mortality rate, it was the clinical symptoms associated with this outbreak that attracted interest and worry from scientists and health officials worldwide when the outbreak was first reported.

As Tang and colleagues detail in their article, a large proportion of the infected individuals (including all but one of the patients who died) showed symptoms of Streptococcal toxic shock syndrome (STSS), which had not previously been observed in patients infected with S. suis. However, as Tang and colleagues show, the pathogen in the recent outbreak (as well as in an earlier outbreak in Sichuan province in 1998 that killed 14 of 25 reported patients) was clearly a strain of S. suis. As they describe, both human outbreaks were closely linked to outbreaks in the local pig populations, and there is no reason to believe that any of the cases had been caused by human-to-human transmission.

One of the key questions that arose when the recent outbreak was first reported is whether a new and more virulent strain of S. suis has emerged in China. Tang and colleagues did a genetic study of the S. suis bacteria that they isolated from the Chinese outbreaks to look for unusual characteristics that could explain why these outbreaks were so severe. They did find some differences between the isolates from the two Chinese outbreaks (which appear very similar to each other) and other virulent strains of S. suis. However, more detailed studies are needed before it is clear whether any of these differences are important in explaining why some strains of S. suis are so lethal.

In an accompanying Perspective article, Shiranee Sriskandan and Joshua Slater suggest that S. suis infection “should now be in the list of differential diagnoses when clinicians encounter patients with unexplained sepsis who have a history of exposure to pigs.” They conclude that “the emergence of any new zoonotic disease [an animal disease than can be transmitted to humans] associated with high mortality is of global concern” and call for “international collaboration … to clarify differences between isolates circulating in different regions of the world.”

Andrew Hyde | alfa
Further information:
http://www.plosmedicine.org/
http://www.who.int/csr/don/2005_08_03/en/

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>