Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists apply a mathematical method that refines the contour of tumors to image analysis to improve their treatment

05.04.2006


Cancer treatment needs refinement. Any method aimed at treating a tumor, from extirpation to radiotherapy, requires a precise knowledge of the cancerous tumor margins so that the intervention on it may be performed in such a way that the possibilities of healing are maximised and the effects on surrounding healthy tissues are minimised. A group of researchers from the Department of Mathematics at the Universitat Jaume I in Castelló have implemented a mathematical method that is applied to medical imaging analysis, which enables to determine the margins of a tumor in the prostate, lung or bladder.



In most cases, the task of delimitating the contour of a tumor is carried out manually by a specialist. According to his or her experience, the doctor draws the perimeter within which he or she locates the cancerous tissue on an image obtained by computerised axial tomography (CAT) or magnetic resonance (MR) images. This perimeter may vary slightly depending on the professional who traces it. The method developed by the mathematicians at the UJI does away with such a great subjective variability, and enables a single, more objective and standardised confidence interval to be obtained for each tumor type and patient depending on his or her characteristics.

“What we have done is to define an average and most adjusted confidence interval possible from a series of contours delineated by various professionals on one same tumor, in such a way that it only surrounds the tissue that is considered cancerous and leaves any surrounding tissue which is not to be submitted to treatment unharmed”, as Ximo Gual, the person in charge of the research, explains.


By combining concepts of geometry, statistics and probability, the scientists at the UJI in cooperation with the radiotherapist oncology service at the Hospital Universitari La Fe in Valencia have developed a standard method for prostate cancer cases in patients aged 40-60 years. “All that remains now is to incorporate these mathematical formulae into the software used by medical teams”, Gual points out. The idea is that the machine can automatically write the confidence interval on the contour of the tumor previously drawn by the specialist.

However, the subjectivity of the health professionals is not the only variable that affects the task of determining the margins of a tumor. Indeed, this internal organ motion itself hinders the identification and subsequent monitoring of cancerous tissue. This is particularly obvious in the case of lungs. The problem is that the CAT or MR images corresponding to the same patient but taken on different days do not fit owing to internal organ motion, even though the external cut-off at which the images are taken is the same on each occasion.

“Our aim is to make progress in our research in order to achieve a 3D contouring of the tumor. The idea is to rebuild the tumor in 3D from crosscut images, and to define the three-dimensional confidence interval that accounts for the variability due to internal organ motion”, Ximo Gual explains.

Hugo Cerdà | alfa
Further information:
http://www.uji.es/ocit/noticies/detall&id_a=6081899

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>