Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dangerous glucose-hungry cervical tumors can be detected using PET scans

03.04.2006


Cervical cancers that take up a lot of blood sugar, or glucose, are more resistant to treatment than those that are less glucose-hungry, according to research at Washington University School of Medicine in St. Louis. The researchers also found that the high glucose-uptake tumors can be identified with PET scans, which are already routinely used to determine tumor size and lymph node involvement in cervical cancer patients.



PET scans monitor the amount of a radioactive glucose tracer absorbed by cells, so the brightness of the image reveals how much glucose a tumor takes up. The results of the research team’s analysis indicate that PET scans can be used to better determine prognosis in cervical cancer patients.

"Cervical tumors vary more in their glucose uptake than other kinds of cancer, making glucose uptake a very useful indicator for cervical cancers," says Perry W. Grigsby, M.D., a radiation oncologist with the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "We found that the tumors with higher uptake were associated with lower survival rates and lower disease-free survival rates."


In a report published in the April issue of Gynecological Oncology, the researchers summarized their findings for 96 cervical cancer patients who underwent PET scans before radiation and chemotherapy were initiated.

Analysis showed that 71 percent of patients whose tumors had a glucose uptake value below the median value of 10.2 survived five years without a recurrence of their disease. In contrast, 52 percent of those whose glucose uptake measured above 10.2 went for five years without a recurrence.

Since submitting their findings, the team has continued their investigation with additional patients, who now number near 250. The trend of lower five-year disease-free survival with higher tumor glucose uptake has been born out in the additional patients.

Further, the continuing study has clearly demonstrated that the overall (disease-free and disease-recurring) five-year survival rate was lower in the group of patients whose tumor glucose uptake was above the median of 10.2.

"Our clinical experience has taught us that standard therapy, which includes both chemotherapy with cisplatin and radiation treatments, doesn’t seem to be able to cure these cancers if their glucose metabolism is high," says Grigsby, professor of radiation oncology, of nuclear medicine and of obstetrics and gynecology. "We don’t yet know what therapy will be more effective in these cases. For the time being, we’re closely watching the response of the tumor to treatment and surgically removing the tumor and surrounding tissue when necessary."

To improve treatment options in the future, Grigsby is initiating a study to uncover the cellular mechanisms that are altered in tumors that uptake a lot of glucose.

"I’ve looked at the proteins that transport glucose into tumor cells, and I haven’t seen any significant differences between the glucose transporters in tumors with high glucose uptake and those with low glucose uptake," Grigsby says. "So we’re taking a different approach.

We’re going to biopsy tumors over the course of treatment. Then we’ll look for which genes change activity during treatment. If we can find predictable changes, they may lead us to better treatments for the more-resistant cervical tumors."

Gwen Ericson | EurekAlert!
Further information:
http://www.wustl.edu

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>