Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study Elucidates Relationship Between "Parkinsonian Personality" and Dopamine

31.10.2001


Scientists have long noted that people suffering from Parkinson’s disease commonly exhibit a specific personality type characterized by, among other things, a lower-than-average tendency to seek out new experiences. In explanation, investigators suggested that this trait was rooted in an inability to reap the pleasurable rewards of increased dopamine levels normally brought about by new stimuli because the disease destroys the neurotransmitter. Previous studies of personality and dopamine activity in Parkinson’s patients involved subjects receiving treatment for their disease. Now, for the first time, scientists have examined the link between personality and Parkinson’s in patients yet to receive medication. The report, published in the current issue of the Proceedings of the National Academy of Sciences indicates that, in fact, dopamine is not involved in regulating the low-novelty-seeking trait associated with Parkinson’s.



Valtteri Kaasinen of the University of Turku in Finland and colleagues studied 61 patients who had been diagnosed with Parkinson’s within the past five years but were not taking medication and compared them to a control group of 45 healthy subjects. Using personality questionnaires, the scientists compared traits such as novelty seeking and harm avoidance between the two groups. Unlike previously reported studies involving medicated patients, the correlation between low novelty seeking and Parkinson’s was not highly significant. The authors suggest the previously demonstrated link may have been due in part to the medication administered to treat the disease. Parkinson’s patients did, however, score significantly higher than control subjects for the harm avoidance personality trait, often associated with anxiety and depression. But the authors note that this trait is not disease-specific and "possibly reflects a psychological response to a chronic disease."

The team next investigated the explicit role of dopamine in mediating the personality of a Parkinson’s patient. Using positron emission tomography (PET), the scientists studied the uptake of radioactively labeled L-DOPA (a precursor to dopamine) in the brains of 47 of the Parkinson’s patients. Participants with high scores for harm avoidance demonstrated increased uptake of L-DOPA in the brain’s right caudate region. But patients with low scores for novelty seeking did not show a similar reaction to L-DOPA. "Although the results of this study are not in disagreement with the concept of low-novelty-seeking personality type in Parkinson’s disease," the authors conclude, "the personality type does not seem to be dopamine dependent."

Sarah Graham | Scientific American
Further information:
http://www.sciam.com/news/103101/2.html

More articles from Health and Medicine:

nachricht Cystic fibrosis alters the structure of mucus in airways
28.06.2017 | University of Iowa Health Care

nachricht Mice provide insight into genetics of autism spectrum disorders
28.06.2017 | University of California - Davis

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

High conductive foils enabling large area lighting

29.06.2017 | Power and Electrical Engineering

Designed proteins to treat muscular dystrophy

29.06.2017 | Life Sciences

Climate Fluctuations & Non-equilibrium Statistical Mechanics: An Interdisciplinary Dialog

29.06.2017 | Seminars Workshops

VideoLinks
B2B-VideoLinks
More VideoLinks >>>