Could also protect against other intracellular bacterial pathogens
When bacterial pathogens attack the surface of a cell, vaccine-induced antibodies can mount a formidable defense and fend off the bad bugs. The trouble comes when antibodies cannot recognize the pathogen because the bacteria have infected the cell and are hidden, growing inside the cells wall.
To mount a defense against these cloaked attackers, Darren Higgins, Associate Professor of Microbiology at Harvard Medical School, and H.G. Archie Bouwer, Immunology Research Scientist at the Earle A. Chiles Research Institute and Portland VA Medical Center, have developed a vaccine strategy for generating an attenuated strain of an intracellular bacterial pathogen. The study appears in the PNAS online early edition the week of March 20, 2006. The vaccine approach could also protect against other intracellular bacterial pathogens, such as tularemia.
Judith Montminy | EurekAlert!
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