Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saliva Component May Predict Future Oral Bone Loss

13.03.2006


Researchers at the University at Buffalo have identified two components of saliva that may serve as the basis for novel tests to determine the risk for future loss of the bone that holds teeth in place.



By comparing dental X-rays of 100 patients with analyses of their saliva, the researchers found that higher-than-normal levels of a salivary protein called IL-1-beta were associated with increased bone loss.

The level of another protein, osteonectin, was inversely proportional to bone loss, suggesting this marker may serve as a measure of periodontal health.


Results of the research, a collaboration between the UB School of Dental Medicine and the UB School of Public Health and Health Professions, were presented today (March 10, 2006) at the annual meeting of the International Association of Dental Research being held in Orlando, Fla.

"These results show that above-average levels of IL-1 beta in saliva may prove to help the dentist decide whether or not to treat the dental patient for periodontal disease," said lead researcher Frank Scannapieco, D.D.S., Ph.D., professor and chair of the Department of Oral Biology in the UB dental school.

"Currently there is no early warning test for bone-loss activity," Scannapieco added. "We can measure gum pocket depth, or the amount of bone remaining on an X-ray, but these methods only tell us how much damage already has been done. If these findings hold up in future longitudinal studies, the dental practitioner might use a test to decide what interventions are needed for the patient, and perhaps the frequency for recall visits.

"This biomarker test also could provide a quick and easy way to monitor patients over the long-term and to determine if a particular treatment is working," he said.

Periodontal bone loss is a serious oral-health condition that can cause teeth to loosen and fall out. The availability of a simple test would reduce the need to submit every patient to expensive, time-consuming and often uncomfortable X-rays and pocket-probing exams, which measure how much of the tooth-supporting bone already has been lost due to periodontal (gum) disease. Such a test also may help a dentist decide how often a patient needs tooth cleaning.

Previous studies had identified specific protein biomarkers of bone destruction in fluid collected from gum crevices in patients with active periodontal disease, but collecting enough of this fluid for analysis can be tedious and time consuming, whereas saliva is plentiful and easily collected.

The research team now is performing follow-up studies to determine the validity of their results.

Additional UB researchers on the team were Patricia Yen Bee Ng, Maureen Donley, D.D.S., Ernest Hausmann, D.M.D., Ph.D., Alan Hutson, Ph.D., Jean Wactowski-Wende, Ph.D., and Paul Bronson. Edward Rossomando, Ph.D., from the University of Connecticut, also contributed to the study.

The research was supported by a grant from the National Institute of Dental and Craniofacial Research.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York.

Lois Baker | EurekAlert!
Further information:
http://www.buffalo.edu

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>