Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists use PET scans to monitor lung inflammation noninvasively

10.03.2006


A noninvasive approach for assessing lung inflammation should accelerate efforts to develop drugs for inflammatory lung conditions like cystic fibrosis and pneumonia, scientists at Washington University School of Medicine in St. Louis report.


In this PET image, the arrow shows inflammation of the lungs.



Researchers have used positron emission tomography (PET) scans to monitor artificially induced inflammation in the lungs of healthy volunteers. The new imaging process may help doctors monitor the conditions of patients with inflammatory lung diseases and should make it easier to test potential anti-inflammatory drugs in trials.

"Until now, when we wanted to assess whether a new drug decreased lung inflammation, the options for specifically measuring active inflammation were not pleasant," says lead author Delphine Chen, M.D., chief resident in nuclear medicine at the medical school’s Mallinckrodt Institute of Radiology. "We could perform a bronchoscopy and gather samples directly from the breathing passages, or we could have patients inhale a saline solution and cough it back up."


To make it possible to detect lung inflammation with PET, Chen and her colleagues employed an imaging technique commonly used to diagnose cancer and monitor its treatment. Scientists reported the results in a paper published online by The Journal of Applied Physiology.

Senior author Daniel P. Schuster, M.D., professor of medicine and of radiology, hopes the new imaging process will make it possible to give new drugs trial runs.

"Full-scale clinical trials are costly in terms of both time and dollars spent, and right now it’s very difficult to find intermediate steps that allow us to build confidence in a drug’s effectiveness before taking that plunge," Schuster says.

With the new PET procedure, Schuster says, researchers developing anti-inflammatory drugs can test the drugs’ effects in less expensive trials involving smaller groups of healthy volunteers and patients.

"If the drug passes those tests, then you can say, okay, let’s see in a full-scale trial if the drug actually has an impact on some important patient-centered outcome like mortality or disease progression," he says.

To create areas of limited lung inflammation in healthy volunteers, researchers used a technique originally developed by scientists at the National Institutes of Health. It involves the injection, via bronchoscope, of a small amount of endotoxin into a lung segment.

"Endotoxin is a purified bacterial substance that triggers inflammation," Schuster says. "The technique we used keeps that inflammation compartmentalized to a small region in the lung, ensuring that the inflammation doesn’t become systemic."

Another research group previously had shown that this artificial inflammation could be used to test potential drugs, but they followed the effects of the drugs via a second insertion of the bronchoscope into the volunteers’ tracheas.

Chen and her colleagues instead injected volunteers with fluorodeoxyglucose (FDG), a form of sugar readily detectable by PET, and continuously monitored the lungs for 60 minutes to see how much FDG appeared there.

Scientists already have completed a trial to test the new imaging procedure’s ability to detect inflammation in cystic fibrosis patients that will be published soon in The American Journal of Respiratory and Critical Care Medicine.

Michael Purdy | EurekAlert!
Further information:
http://www.wustl.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>