Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Serotonin may play role in hardening of the arteries

06.03.2006


Findings may explain link between lifestyle and heart disease



A less active brain serotonin system is associated with early hardening of the arteries, according to a study presented today by University of Pittsburgh researchers at the 64th Annual Scientific Conference of the American Psychosomatic Society in Denver. These findings, which are the first to establish a link between serotonin messages in the brain and atherosclerosis, could lead to an entirely new strategy for preventing heart disease and stroke, say the researchers.

"Many of the known risk factors for heart disease and stroke – high blood pressure and cholesterol, obesity, diabetes, smoking and lack of exercise – can, to some extent, be controlled by our lifestyle choices," said Matthew F. Muldoon, M.D., M.P.H., associate professor of medicine, University of Pittsburgh School of Medicine. "Until now, no one had studied the possibility that brain abnormalities could explain why some people make these poor lifestyle choices and have multiple risk factors for heart disease."


In the study being presented today, which included 244 adult volunteers between the ages of 30 and 55 years, researchers measured serotonergic activity using a pharmacological approach and carotid artery thickness using ultrasonography. At the time of testing, participants were free of clinically evident vascular disease. Yet, those with low levels of serotonergic function were more likely to have thickening of the carotid artery than those with higher levels.

"If, through further studies, we can establish that risk factors for heart disease and stroke are, in part, controlled by the serotonin systems in the brain, it could open a whole new avenue for preventing heart disease and stroke," said Dr. Muldoon.

Serotonin is a type of neurotransmitter, a chemical that sends messages between neurons in the brain. It is thought to play an important role in the regulation of mood, appetite and blood pressure. Previous studies by Dr. Muldoon and colleagues have found that people who get little exercise, are overweight, have high blood pressure, blood sugar and cholesterol have low levels of serotonergic function. A number of research studies have established a link between serotonin and mood. However, until now, the relationship between the serotonin system and atherosclerosis had remained unstudied.

Jocelyn Uhl Duffy | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>