Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Primary biliary cirrhosis more prevalent around toxic waste sites in NYC

02.03.2006


Significant cluster found on Staten Island



According to a new study, exposure to toxins from hazardous waste sites may be a significant risk factor for developing primary biliary cirrhosis (PBC). Published in the March 2006 issue of Hepatology, researchers found significant clusters of the disease near Superfund toxic waste sites (SFS) and that the majority of patients in New York City who need liver transplants because of PBC, reside near SFS. Hepatology is published on behalf of the society by John Wiley & Sons, Inc., and is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

PBC is an uncommon liver disease of unknown cause, though it reportedly appears in geographic clusters. Researchers, led by Aftab Ala, M.D. of Mount Sinai School of Medicine in New York City, examined the prevalence and potential clustering of PBC near New York City’s most toxic waste sites, which are state-designated SFS.


The researchers collected zip code data on 172 patients in New York City in need of orthotopic liver transplant (OLT) between 1995 and 2003 due to either PBC or primary sclerosing cholangitis (PSC). They compared the patients’ zip codes to zip codes of known SFS in the city. Of the city’s 174 zip codes, 89 included or bordered SFS and 85 did not.

The researchers then calculated the expected prevalence of PBC-OLT and PSC-OLT, adjusting for demographic characteristics. They compared the mean standardized prevalence ratios in zip codes containing or adjacent to a SFS to the remaining zip codes. Lastly, they utilized SaTScan, a statistical software package, to detect specific clusters.

"The prevalence ratio of PBC-OLT, not PSC-OLT, was significantly higher in zip codes containing or adjacent to SFS," the authors report. The standardized prevalence ratio of PBC-OLT cases near SFS was statistically significantly higher than in zip codes that did not have, nor border with, a toxic site. Meanwhile, the standardized prevalence ratio of PSC-OLT cases near SFS was not statistically different from zip codes without a toxic site nearby. The density of SFS and the prevalence ratio of PBC-OLT were both highest in the borough of Staten Island, while Manhattan had the lowest values for both.

The cluster-detection software uncovered five clusters of PBC-OLT. One was on Staten Island, two were in Brooklyn, and two in Queens. SFS near these clusters were contaminated by volatile organic compounds, like benzene and toluene, and chlorinated hydrocarbons, like tri- and tetra-chloroethylene. The cluster on Staten Island was statistically significant, and located near a SFS contaminated with volatile aromatic hydrocarbons and trichloroethylene. "This is the first epidemiological study to show a statistically significant clustering of PBC patients near known sources of environmental toxins and one of relatively few studies linking proximity to SFS to a specific disease," the authors write. Though the exact mechanism by which proximity to toxins may increase PBC patient exposure is not clear, the authors suggest inhalation is the likely method. Still, confounding factors may play a role, such as socioeconomics that influence where people live.

"Our observations further support the hypothesis that environmental toxin exposure is a risk factor for PBC," the authors conclude. They urge researchers in other locations to further investigate the association.

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/hepatology
http://www.wiley.com

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>