Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vitamin D inhibits progression of some prostate cancers

09.02.2006


Vitamin D can inhibit the spread of prostate cancer cells by limiting the activity of two specific enzymes, University of Rochester Medical Center scientists report.



The finding means that vitamin D could provide beneficial treatment to prostate cancer patients with high levels of the enzymes, the scientists said.

"We wanted to know the targets of vitamin D so we would know which patients would respond better," said Yi-Fen Lee, Ph.D., an assistant professor of Urology at the Medical Center who led the research.


The journal Carcinogenesis published the findings by Lee and her fellow researchers in its January issue. The research was conducted in test tubes using human prostate cancer cells lines.

Research evidence increasingly has indicated that vitamin D suppresses the progression of cancer. Medical Center scientists discovered that vitamin D significantly limits the ability of prostate cancer cells to invade healthy cells by reducing the activity of two enzymes – proteases called matrix metalloproteinase and cathepsin. Vitamin D also increases the level of counterpart enzymes that inhibit matrix metalloproteinase and cathepsin, the Rochester scientists found.

Vitamin D, however, had little effect on plasminogen activators, which also are important in the spread of prostate cancer.

"Each individual is different so the therapy could be custom made for each person," Lee said.

The vitamin D used in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. But Lee and other scientists at the Medical Center’s James P. Wilmot Cancer Center do not advise taking large amounts of vitamin D without medical supervision.

"This high dose has some side effects, including increasing blood calcium levels and causing kidney problems" said Edward M. Messing, M.D., chair of Urology at the Medical Center. "It should not be taken without prescription and a physician monitoring the side effects."

Lee is investigating whether there are medicines or other vitamins, such as vitamin E, that could enhance the anti-cancer effects of vitamin D without increasing toxicity.

"The best way to get vitamin D is to drink milk, get modest exposure to the sun, and take a vitamin pill to enrich the vitamin D, which might prevent cancer," Lee said.

In addition to Lee, authors of the Carcinogenesis article include Bo-Ying Bao, a University of Rochester graduate student, and Shauh-Der Yeh of the Department of Urology at Taipei Medical University.

Michael Wentzel | EurekAlert!
Further information:
http://www.urmc.rochester.edu

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>