Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vitamin D inhibits progression of some prostate cancers

09.02.2006


Vitamin D can inhibit the spread of prostate cancer cells by limiting the activity of two specific enzymes, University of Rochester Medical Center scientists report.



The finding means that vitamin D could provide beneficial treatment to prostate cancer patients with high levels of the enzymes, the scientists said.

"We wanted to know the targets of vitamin D so we would know which patients would respond better," said Yi-Fen Lee, Ph.D., an assistant professor of Urology at the Medical Center who led the research.


The journal Carcinogenesis published the findings by Lee and her fellow researchers in its January issue. The research was conducted in test tubes using human prostate cancer cells lines.

Research evidence increasingly has indicated that vitamin D suppresses the progression of cancer. Medical Center scientists discovered that vitamin D significantly limits the ability of prostate cancer cells to invade healthy cells by reducing the activity of two enzymes – proteases called matrix metalloproteinase and cathepsin. Vitamin D also increases the level of counterpart enzymes that inhibit matrix metalloproteinase and cathepsin, the Rochester scientists found.

Vitamin D, however, had little effect on plasminogen activators, which also are important in the spread of prostate cancer.

"Each individual is different so the therapy could be custom made for each person," Lee said.

The vitamin D used in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. But Lee and other scientists at the Medical Center’s James P. Wilmot Cancer Center do not advise taking large amounts of vitamin D without medical supervision.

"This high dose has some side effects, including increasing blood calcium levels and causing kidney problems" said Edward M. Messing, M.D., chair of Urology at the Medical Center. "It should not be taken without prescription and a physician monitoring the side effects."

Lee is investigating whether there are medicines or other vitamins, such as vitamin E, that could enhance the anti-cancer effects of vitamin D without increasing toxicity.

"The best way to get vitamin D is to drink milk, get modest exposure to the sun, and take a vitamin pill to enrich the vitamin D, which might prevent cancer," Lee said.

In addition to Lee, authors of the Carcinogenesis article include Bo-Ying Bao, a University of Rochester graduate student, and Shauh-Der Yeh of the Department of Urology at Taipei Medical University.

Michael Wentzel | EurekAlert!
Further information:
http://www.urmc.rochester.edu

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>