Propose new approach for better treatment of deadly condition
A Mayo Clinic research team has challenged the accepted theory on the cause of sepsis -- a condition in which the bodys cells generate fever, shock and often death. Sepsis is thought to occur when poisons from bacterial infection interfere with the cells. The Mayo researchers challenge that long-held concept with a new theory in an opinion piece in the current issue of Trends in Molecular Medicine. Their findings suggest that sepsis begins with a change in certain cellular receptors that then provoke widespread inflammation, even in the absence of bacteria or their poisons.
"We think people have been focusing too exclusively on a single causal factor of sepsis for the last 150 years and, as a result, therapeutically aiming at the wrong target -- the bacteria and the poisons they produce," says senior author Jeffrey Platt, M.D. "Thats why the death rate remains so high despite efforts to block the poisons."
Robert Nellis | EurekAlert!
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