Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity may be factor in accelerated type I diabetes in some patients

06.02.2006


Obesity, long known as a cause of type II diabetes, may accelerate the onset of type 1 diabetes in some – but not all – groups of younger patients, according to research at Wake Forest University School of Medicine and six clinical sites nationally.



"The increasing prevalence of childhood obesity may substantially account for the younger age at onset of type 1 diabetes observed in various populations," said the research team, writing in the February issue of Diabetes Care.

But the connection to obesity was observed only in those patients in which the production of insulin by beta cells in the pancreas already had been severely compromised, said Ralph B. D’Agostino Jr., Ph.D., professor of public health sciences-biostatistics at the medical school, and a co-author of the paper.


D’Agostino also is deputy director of the study’s National Coordinating Center, which is located at the School of Medicine. In the paper, the researchers said, "These patients have compromised pancreatic beta cell function and can no longer compensate for the additional metabolic demands associated with higher body mass index."

Body mass index (BMI) is computed from weight and height; a BMI over 30 indicates obesity. The body uses insulin in metabolizing carbohydrates and in regulating glucose (blood sugar) levels in the body, and diabetes results when there is insufficient insulin to meet the need.

"Whether the reduced beta cell function is solely due to an autoimmune-mediated attack or whether non-autoimmune factors also contribute is a distinction that we are unable to make in this study," the researchers said.

The researchers did determine that there was no statistical association between age of onset and BMI in those diabetes patients who still had relatively well-preserved beta cell function.

The researchers also found that low birth weight may also be a factor in accelerating the onset of type 1 diabetes, which is now considered an autoimmune disorder, in which the body’s own defenses turn on it.

As birth weight decreased, the age at which type 1 diabetes appeared advanced. The study was part of the Search for Diabetes in Youth, and involved 449 participants who were under 20 at the time of the diabetes diagnosis.

The six clinical sites were the University of Colorado Health Sciences Center in Denver, the University of South Carolina in Columbia, Children’s Hospital Medical Center in Cincinnati, Children’s Hospital and Regional Medical Center in Seattle, the Sansum Medical Research Institute in Santa Barbara, Calif., and University of Hawaii.

Search for Diabetes in Youth is trying to determine the prevalence and incidence of childhood diabetes and document how much childhood diabetes is type 1, how much is type 2, and how much is due to other rare causes. The study is funded by the Centers for Disease Control and Prevention and the National Institute of Diabetes and Digestive and Kidney Diseases.

According to the American Diabetes Association, type 1 diabetes results from the body’s failure to produce insulin, the hormone that "unlocks" the cells of the body, allowing glucose to enter and fuel them. Type 2 diabetes results from insulin resistance (a condition in which the body fails to properly use insulin), combined with relative insulin deficiency.

Robert Conn | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

nachricht Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>