Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity may be factor in accelerated type I diabetes in some patients

06.02.2006


Obesity, long known as a cause of type II diabetes, may accelerate the onset of type 1 diabetes in some – but not all – groups of younger patients, according to research at Wake Forest University School of Medicine and six clinical sites nationally.



"The increasing prevalence of childhood obesity may substantially account for the younger age at onset of type 1 diabetes observed in various populations," said the research team, writing in the February issue of Diabetes Care.

But the connection to obesity was observed only in those patients in which the production of insulin by beta cells in the pancreas already had been severely compromised, said Ralph B. D’Agostino Jr., Ph.D., professor of public health sciences-biostatistics at the medical school, and a co-author of the paper.


D’Agostino also is deputy director of the study’s National Coordinating Center, which is located at the School of Medicine. In the paper, the researchers said, "These patients have compromised pancreatic beta cell function and can no longer compensate for the additional metabolic demands associated with higher body mass index."

Body mass index (BMI) is computed from weight and height; a BMI over 30 indicates obesity. The body uses insulin in metabolizing carbohydrates and in regulating glucose (blood sugar) levels in the body, and diabetes results when there is insufficient insulin to meet the need.

"Whether the reduced beta cell function is solely due to an autoimmune-mediated attack or whether non-autoimmune factors also contribute is a distinction that we are unable to make in this study," the researchers said.

The researchers did determine that there was no statistical association between age of onset and BMI in those diabetes patients who still had relatively well-preserved beta cell function.

The researchers also found that low birth weight may also be a factor in accelerating the onset of type 1 diabetes, which is now considered an autoimmune disorder, in which the body’s own defenses turn on it.

As birth weight decreased, the age at which type 1 diabetes appeared advanced. The study was part of the Search for Diabetes in Youth, and involved 449 participants who were under 20 at the time of the diabetes diagnosis.

The six clinical sites were the University of Colorado Health Sciences Center in Denver, the University of South Carolina in Columbia, Children’s Hospital Medical Center in Cincinnati, Children’s Hospital and Regional Medical Center in Seattle, the Sansum Medical Research Institute in Santa Barbara, Calif., and University of Hawaii.

Search for Diabetes in Youth is trying to determine the prevalence and incidence of childhood diabetes and document how much childhood diabetes is type 1, how much is type 2, and how much is due to other rare causes. The study is funded by the Centers for Disease Control and Prevention and the National Institute of Diabetes and Digestive and Kidney Diseases.

According to the American Diabetes Association, type 1 diabetes results from the body’s failure to produce insulin, the hormone that "unlocks" the cells of the body, allowing glucose to enter and fuel them. Type 2 diabetes results from insulin resistance (a condition in which the body fails to properly use insulin), combined with relative insulin deficiency.

Robert Conn | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>