Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells. The paper by McDaniel et al., “Remodeling of the mammary microenvironment following lactation promotes breast tumor cell metastasis,” appears in the February issue of The American Journal of Pathology and is accompanied by a commentary.
This work also highlights an important shift in thinking about what influences cancers to metastasize: the move from studying specific gene mutations to studying the tumor environment. The focus on the tumor environment, or stroma, has been gaining strength in recent years, as detailed in the commentary by Sonnenschein and Soto.
The human breast undergoes dramatic changes during the course of pregnancy, lactation, and involution (the process by which the milk-producing tissue is reabsorbed and the breast returns to “normal”). These processes require mammary cells to proliferate, differentiate, and finally die, events that are partly driven by changes in the environment surrounding the cells, or extracellular matrix. How these changes affect the outcome of breast cancer is of great interest, especially considering the epidemiological link between breast cancer after pregnancy and poor prognosis.
Audra Cox | EurekAlert!
Speed data for the brain’s navigation system
06.12.2016 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
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