Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Intensive postoperation surveillance improves the survival of patients with stage II colorectal cancer

02.02.2006


Systematic postoperative surveillance of patients with rectal and colorectal cancer has demonstrated to produce an improvement in the survival of these patients. Nevertheless, it is currently discussed whether a more intensive surveillance strategy would provide significant advantage compared to a less aggressive strategy. The methodology currently used for testing and the frequency tests are applied are highly heterogeneous. So, in order to compare the efficiency of two surveillance strategies, a standard strategy and an intensive strategy, physicians of Hospital Clínic conducted a prospective, multicentre and randomised study in patients affected by this type of cancer. This trial, supported by the Medical Technology Agency of the Catalan Government, was led by Dr. Francisco Rodríguez-Moranta and Dr. Antoni Castells, from the IDIBAPS Physiopathology of the Gastrointestinal Lesions Group, and had the collaboration of specialists of Hospital de Terrassa and Hospital General de Vic. The results of these comparison were published in Journal of Clinical Oncology (24(3):386-93), and showed that the most intensive therapy benefited patients in certain stages of cancer and patients with rectal lesions, whose overall survival was increased.



To conduct this study, 259 patients from the three centres with colorectal cancer in stage II or III (which are intermediate states in a scale ranging I-IV) were recruited and were randomly distributed in two surveillance experimental groups. In the first group, 132 patients received the simplest standard surveillance, consisting in the clinical evaluation and in the monitoring of blood tumour markers every three months. In the second group, the 127 patients were applied a strategy that, in addition to the standard, consisted in an abdominal CT-scan or ultrasonography, chest x-ray and colonoscopy. Both groups of patients were similar with respect to baseline characteristics as disease, tumour recurrence rate and type of tumour. After 48 months of follow-up, researchers did not detect significant difference in the overall survival between patients the of the two groups. However, as specific subgroups were analysed, the intensive strategy was associated to a higher survival, in number of years, in patients of stage II tumours and those with rectal lesions. Thus, this type of surveillance benefited this subtype of patients since relapse could be detected earlier. Particularly, colonoscopy was the method responsible for the detection of the highest proportion (44%) of recurrences of operable tumours.

According to the authors, this invasive strategy would improve the prognosis of patients with stage II colorectal cancer and also patients with rectal lesions. In this sense, they recommend the periodical colonoscopy during the first 5 years of postoperatory follow-up, a practice that is already applied in Hospital Clínic. The level of cost efficiency of this strategy is justified by the higher healing rate in case of relapse, since tumours are detected in their onset. Nevertheless, this strategy does not show more efficiency in other cases and it is important to continue to search for the most specific techniques for every case in order to avoid nonessential health expense. Although these results do not permit to define the perfect strategy for the follow-up of all patients with colorectal cancer, it permits to establish a strategy suitable for an important subgroup of patients (nearly half of patients suffering from this disease). The journal has written an editorial comment about the article in which both the study and the Catalan Government Support are acclaimed.

Àlex Argemí Saburit | alfa
Further information:
http://www.idibaps.ub.edu

More articles from Health and Medicine:

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

nachricht Flexible sensors can detect movement in GI tract
11.10.2017 | Massachusetts Institute of Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

Im Focus: Small collisions make big impact on Mercury's thin atmosphere

Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.

Recent modeling along with previously published results from NASA's MESSENGER spacecraft -- short for Mercury Surface, Space Environment, Geochemistry and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

Conference Week RRR2017 on Renewable Resources from Wet and Rewetted Peatlands

28.09.2017 | Event News

 
Latest News

A single photon reveals quantum entanglement of 16 million atoms

16.10.2017 | Physics and Astronomy

The melting ice makes the sea around Greenland less saline

16.10.2017 | Earth Sciences

On the generation of solar spicules and Alfvenic waves

16.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>